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1. WO2000036973 - OPTICAL METHODS AND SYSTEMS FOR CERVICAL SCREENING

Publication Number WO/2000/036973
Publication Date 29.06.2000
International Application No. PCT/US1999/030902
International Filing Date 23.12.1999
Chapter 2 Demand Filed 20.07.2000
IPC
A61B 5/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
CPC
A61B 5/0071
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
0059using light, e.g. diagnosis by transillumination, diascopy, fluorescence
0071by measuring fluorescence emission
A61B 5/0075
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
0059using light, e.g. diagnosis by transillumination, diascopy, fluorescence
0075by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
A61B 5/0084
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
0059using light, e.g. diagnosis by transillumination, diascopy, fluorescence
0082adapted for particular medical purposes
0084for introduction into the body, e.g. by catheters
A61B 5/0086
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
0059using light, e.g. diagnosis by transillumination, diascopy, fluorescence
0082adapted for particular medical purposes
0084for introduction into the body, e.g. by catheters
0086using infra-red radiation
A61B 5/4331
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
43Detecting, measuring or recording for evaluating the reproductive systems
4306for evaluating the female reproductive systems, e.g. gynaecological evaluations
4318Evaluation of the lower reproductive system
4331of the cervix
Applicants
  • MEDISPECTRA, INC. [US]/[US]
Inventors
  • NORDSTROM, Robert
  • MODELL, Mark
Agents
  • STUTIUS, Wolfgang, E.
  • REES, Dianne, M.
Priority Data
60/113,62423.12.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) OPTICAL METHODS AND SYSTEMS FOR CERVICAL SCREENING
(FR) SYSTEMES ET TECHNIQUES OPTIQUES DESTINES A L'EXAMEN DU COL
Abstract
(EN)
A method and a system is provided for discriminating between healthy cervical tissue and pathologic cervical tissue based on the fluorescence response of the tissue to laser excitation (LIF) and the backscatter response to illumination by white light (in the spectral range of 360 to 750 nm). Combining LIF and white light responses, as well as evaluating a spatial correlation between proximate cervical tissue sites in conjunction with a statistically significant 'distance' algorithm, such as the Mahalanobis distance between data sets, can improve the discrimination between normal and abnormal tissue. The results may be displayed in the form of a map of the cervix representing the suspected pathology.
(FR)
L'invention concerne une technique et un système permettant de distinguer les tissus sains du col utérin des tissus pathologiques, d'après la réponse de fluorescence du tissu à la fluorescence induite par laser et sa rétrodiffusion de lumière blanche (dans l'intervalle de 360 à 750 nm). Le rapprochement des réponses au laser et à la lumière blanche, ainsi qu'une évaluation de la corrélation spatiale entre sites tissulaires proches avec un algorithme de « distance » statistiquement significatif tel que la distance de Mahalanobis entre ensembles de données, peut améliorer la discrimination entre tissus normaux et anormaux. Les résultats peuvent être présentés sous forme d'une carte du col de l'utérus représentant la pathologie présumée.
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