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Machine translation
1. (WO2000036918) METHODS AND COMPOSITIONS FOR TREATMENT OF CELL PROLIFERATIVE DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/036918    International Application No.:    PCT/US1999/030575
Publication Date: 29.06.2000 International Filing Date: 21.12.1999
Chapter 2 Demand Filed:    11.07.2000    
IPC:
A61K 31/785 (2006.01), C08B 37/08 (2006.01)
Applicants: MARINE POLYMERS TECHNOLOGIES, INC. [US/US]; 107 Water Street, Danvers, MA 01923 (US)
Inventors: VOURNAKIS, John, N.; (US).
FINKIELSZTEIN, Sergio; (US).
PARISER, Ernest, R.; (US)
Agent: CORUZZI, Laura, A.; Pennie & Edmonds LLP, 1155 Avenue of the Americas, New York, NY 10036 (US)
Priority Data:
09/218,288 22.12.1998 US
Title (EN) METHODS AND COMPOSITIONS FOR TREATMENT OF CELL PROLIFERATIVE DISORDERS
(FR) TECHNIQUES ET COMPOSITIONS PERMETTANT DE TRAITER LES TROUBLES ASSOCIES AUX CELLULES PROLIFERATIVES
Abstract: front page image
(EN)The present invention relates to methods and compositions comprising at least one endothelin antagonist, preferably in combination with a poly-$g(b)-1$m(7)-4-N-acetylglucosamine (p-G1cNAc) polysaccharide matrix, for use in the treatment of cancer and other proliferative diseases. The endothelin antagonist can be a peptide or non-peptide compound, and the p-G1cNAc matrix of the invention is comprised of a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a $g(b)-1$m(7)-4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. The compositions and methods of the invention are useful for inhibiting the growth of tumors and other neoplastic cells and/or for inhibiting the metastasis of neoplastic cells $i(in vivo).
(FR)L'invention concerne des techniques et des compositions comprenant au moins un antagoniste de l'endothéline, de préférence en combinaison avec une matrice polysaccharidique de poly-$g(b)-1$m(7)-4-N-acétylglucosamine (p-G1cNAc), utilisée pour traiter le cancer ou d'autres maladies prolifératives. L'antagoniste de l'endothéline peut être un composé peptidique ou non peptidique, et la matrice p-G1cNAc est constituée d'un polymère de poids moléculaire élevé dont les sucres monosaccharides constituants sont fixés en une conformation $g(b)-1$m(7)-4, est exempte de protéines, et sensiblement exempte d'acides aminés seuls et d'autres contaminants organiques et non organiques. Les compositions et les techniques de cette invention sont utiles pour inhiber la croissance des tumeurs et d'autres cellules néoplasiques et/ou pour inhiber $i(in vivo) les métastases desdites cellules néoplasiques.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)