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1. WO2000031135 - TGF$G(b)1 INHIBITOR PEPTIDES

Publication Number WO/2000/031135
Publication Date 02.06.2000
International Application No. PCT/ES1999/000375
International Filing Date 23.11.1999
Chapter 2 Demand Filed 20.06.2000
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/495 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
495Transforming growth factor (TGF)
C07K 14/71 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
71for growth factors; for growth regulators
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07K 14/495
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
495Transforming growth factor [TGF]
C07K 14/71
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
71for growth factors; for growth regulators
Applicants
  • INSTITUTO CIENTIFICO Y TECNOLOGICO DE NAVARRA, S.A. [ES]/[ES] (AllExceptUS)
  • EZQUERRO SAENZ, Ignacio José [ES]/[ES] (UsOnly)
  • LASARTE SAGASTIBELZA, Juan José [ES]/[ES] (UsOnly)
  • PRIETO VALTUEÑA, Jesús [ES]/[ES] (UsOnly)
  • BORRAS CUESTA, Francisco [ES]/[ES] (UsOnly)
Inventors
  • EZQUERRO SAENZ, Ignacio José
  • LASARTE SAGASTIBELZA, Juan José
  • PRIETO VALTUEÑA, Jesús
  • BORRAS CUESTA, Francisco
Agents
  • DE ELZABURU, Alberto
Priority Data
P 980246524.11.1998ES
Publication Language Spanish (ES)
Filing Language Spanish (ES)
Designated States
Title
(EN) TGF$G(b)1 INHIBITOR PEPTIDES
(ES) PEPTIDOS INHIBIDORES DE TGF$g(b)1
(FR) PEPTIDES INHIBITEURS DE TGF$G(b)1
Abstract
(EN)
Antagonists synthetic peptides which are obtained from TGF$g(b)1 or from its receptors in the organism. It is possible to use either the peptides themselves or the genic sequences which code them and the recombinant systems which express them for the fabrication of compositions used in the treatment of hepatic diseases and more particularly in cases of fibrosis. These compositions may optionally include mimotopes of said active peptides.
(ES)
Péptidos sintéticos antagonistas, obtenidos de TGF$g(b)1 o de sus receptores en el organismo, que pueden ser utilizados en la fabricación, tanto por si solos, como las secuencias génicas que los codifican y los sistemas recombinantes que los expresen, en la fabricación de composiciones útiles para el tratamiento de enfermedades hepáticas y más concretamente en casos de fibrosis. Dichas composiciones pueden incluir opcionalmente mimotopos de dichos péptidos activos.
(FR)
L'invention concerne des peptides synthétiques antagonistes de TGF$g(b)1 ou de ses récepteurs dans l'organisme. On utilise soit les peptides en soi soit les séquences géniques les codant et les systèmes recombinants les exprimant dans la fabrication de compositions utiles pour le traitement de maladies hépatiques et plus particulièrement dans les cas de fibrose. Ces compositions peuvent renfermer éventuellement des mimotopes de ces peptides actifs.
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