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1. WO2000031084 - PROSTAGLANDIN CONJUGATES FOR TREATING OR PREVENTING BONE DISEASE

Publication Number WO/2000/031084
Publication Date 02.06.2000
International Application No. PCT/CA1999/001111
International Filing Date 18.11.1999
Chapter 2 Demand Filed 14.06.2000
IPC
A61K 47/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C07F 9/38 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
28with one or more P-C bonds
38Phosphonic acids ; Thiophosphonic acids
CPC
A61K 47/54
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
A61P 1/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61P 19/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 19/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
08for bone diseases, e.g. rachitism, Paget's disease
A61P 19/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
08for bone diseases, e.g. rachitism, Paget's disease
10for osteoporosis
Applicants
  • MERCK FROSST CANADA & CO. [CA]/[CA] (AllExceptUS)
  • GIL, Laurent [FR]/[CA] (UsOnly)
  • HAN, Yongxin [CA]/[CA] (UsOnly)
  • RUEL, Rejean [CA]/[CA] (UsOnly)
  • YOUNG, Robert, N. [CA]/[CA] (UsOnly)
Inventors
  • GIL, Laurent
  • HAN, Yongxin
  • RUEL, Rejean
  • YOUNG, Robert, N.
Agents
  • MURPHY, Kevin, P.
Priority Data
60/109,30720.11.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROSTAGLANDIN CONJUGATES FOR TREATING OR PREVENTING BONE DISEASE
(FR) CONJUGUES DE LA PROSTAGLANDINE TRAITANT OU PREVENANT LES MALADIES DE L'OS
Abstract
(EN)
This invention relates to prostaglandin-bisphosphonate conjugates. These conjugates are effective for treating or preventing bone diseases such as osteoporosis. These conjugates simultaneously deliver a prostaglandin agent for increasing bone formation and a bisphosphonate agent for inhibiting bone resorption.
(FR)
L'invention porte sur des conjugués prostaglandine-bisphosphonate efficaces dans le traitement de maladies de l'os telles que l'ostéoporose. Lesdits conjugués fournissent simultanément un agent à base de prostaglandine accroissant la formation de l'os, et un agent à base de bisphosphonate empêchant sa résorption.
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