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1. WO2000031075 - CRYSTAL MODIFICATION A OF 8-CYANO-1- CYCLOPROPYL -7-(1S,6S-2, 8-DIAZABICYCLO [4.3.0]NONAN -8-YL)-6- FLUORO-1, 4-DIHYDRO- 4-OXO-3- QUINOLINE CARBOXYLIC ACID

Publication Number WO/2000/031075
Publication Date 02.06.2000
International Application No. PCT/EP1999/008775
International Filing Date 15.11.1999
Chapter 2 Demand Filed 27.03.2000
IPC
C07D 471/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 31/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
02Local antiseptics
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • BAYER AKTIENGESELLSCHAFT [DE]/[DE] (AllExceptUS)
  • HIMMLER, Thomas [DE]/[DE] (UsOnly)
  • HALLENBACH, Werner [DE]/[DE] (UsOnly)
  • RAST, Hubert [DE]/[DE] (UsOnly)
Inventors
  • HIMMLER, Thomas
  • HALLENBACH, Werner
  • RAST, Hubert
Common Representative
  • BAYER AKTIENGESELLSCHAFT
Priority Data
198 54 356.525.11.1998DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) KRISTALLMODIFIKATION A VON 8-CYAN-1- CYCLOPROPYL-7- (1S,6S-2,8 -DIAZABICYCLO -[4.3.0]NONAN -8-YL)-6- FLUOR-1,4- DIHYDRO-4- OXO-3- CHINOLINCARBONSÄURE
(EN) CRYSTAL MODIFICATION A OF 8-CYANO-1- CYCLOPROPYL -7-(1S,6S-2, 8-DIAZABICYCLO [4.3.0]NONAN -8-YL)-6- FLUORO-1, 4-DIHYDRO- 4-OXO-3- QUINOLINE CARBOXYLIC ACID
(FR) MODIFICATION CRISTALLINE A D'ACIDE 8-CYAN-1- CYCLOPROPYL -7-(1S,6S -2,8-DIAZABICYCLO [4.3.0]NONAN -8-YL)-6- FLUOR-1,4- DIHYDRO-4-OXO -3-CHINOLINCARBOXYLIQUE
Abstract
(DE)
Die vorliegende Erfindung betrifft eine definierte Kristallmodifikation von 8-Cyan-1- cyclopropyl -7-(1S,6S-2, 8-diazabicyclo [4.3.0]nonan-8-yl) -6-fluor-1, 4-dihydro-4- oxo-3-chinolincarbonsäure der Formel (I), Verfahren zu ihrer Herstellung sowie ihre Verwendung in pharmazeutischen Zubereitungen. Die Kristallmodifikation ist von anderen Kristallmodifikationen von 8-Cyan-1- cyclopropyl-7-( 1S,6S-2, 8-diazabicyclo [4.3.0]nonan -8-yl)-6- fluor-1, 4-dihydro-4- oxo-3-chinolincarbonsäure der Formel (I) durch ihr charakteristisches Röntgen-Pulverdiffraktogramm und ihr Differentialthermodiagramm unterscheidbar (siehe Beschreibung).
(EN)
The invention relates to a defined crystal modification of 8-cyano-1- cyclopropyl-7- (1S,6S-2,8- diazabicyclo [4.3.0]nonan -8-yl)-6-fluoro -1,4-dihydro -4-oxo-3-quinoline carboxylic acid of formula (I), to methods for producing the same, and to its use in pharmaceutical preparations. The crystal modification can be distinguished from other crystal modifications of 8-cyano -1-cyclopropyl -7-(1S,6S-2, 8-diazabicyclo [4.3.0]nonan -8-yl)-6-fluoro -1,4-dihydro-4- oxo-3-quinoline carboxylic acid of formula (I) by its characteristic X-ray powder diffractogram and its differential thermal diagram.
(FR)
L'invention concerne une modification cristalline définie d'acide 8-Cyan-1- cyclopropyl -7-(1S,6S-2, 8-diazabicyclo [4.3.0]nonan -8-yl)-6- fluor-1,4- dihydro-4- oxo-3-chinolincarboxylique de la formule (I), son procédé de production et son utilisation dans des préparations pharmaceutiques. Cette modification cristalline se distingue d'autres modifications cristallines de l'acide 8-Cyan-1- cyclopropyl -7-(1S,6S-2, 8-diazabicyclo [4.3.0]nonan -8-yl)-6- fluor-1,4- dihydro-4-oxo -3-chinolincarboxylique de la formule (I) par son diagramme de mesure par diffraction des rayons X caractéristique et son diagramme thermique différentiel (voir description).
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