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Machine translation
1. (WO2000029620) METHODS OF FACILITATING VASCULAR GROWTH
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/029620    International Application No.:    PCT/US1999/026743
Publication Date: 25.05.2000 International Filing Date: 12.11.1999
Chapter 2 Demand Filed:    16.03.2000    
IPC:
A61K 38/19 (2006.01), C07K 16/22 (2006.01)
Applicants: CHILDREN'S HOSPITAL OF LOS ANGELES [US/US]; 4650 Sunset Boulevard Los Angeles, CA 90054-0700 (US) (For All Designated States Except US).
SCHWARZ, Margaret [US/US]; (US) (For US Only).
ZHANG, Fangrong [CH/US]; (US) (For US Only).
GEBB, Sarah, A. [US/US]; (US) (For US Only)
Inventors: SCHWARZ, Margaret; (US).
ZHANG, Fangrong; (US).
GEBB, Sarah, A.; (US)
Agent: SIBLEY, Kenneth, D.; Myers, Bigel, Sibley & Sajovec, P.A. P.O. Box 37428 Raleigh, NC 27627 (US)
Priority Data:
60/108,435 13.11.1998 US
Title (EN) METHODS OF FACILITATING VASCULAR GROWTH
(FR) PROCEDES DESTINES A FACILITER LA CROISSANCE VASCULAIRE
Abstract: front page image
(EN)A method of facilitating vascular growth in a subject in need of such treatment comprises inhibiting EMAP II activity in the subject by an amount effective to stimulate vascular growth in the subject (e.g., in the lungs or heart of the subject). Pharmaceutical formulations useful for carrying out such methods (e.g., an antibody that specifically binds to EMAP II in a pharmaceutically acceptable carrier) and screening techniques useful for identifying additional compounds that can be used for carrying out such methods are also disclosed.
(FR)L'invention concerne un procédé destiné à faciliter la croissance vasculaire chez un sujet nécessitant un tel traitement, et consistant à inhiber l'activité de EMAP II (polypeptide activant le monocyte endothélial), par administration audit sujet d'une dose efficace, afin de stimuler la croissance vasculaire (par exemple dans les poumons ou le coeur du sujet). L'invention concerne également des formulations pharmaceutiques, utiles dans l'exécution de tels procédés (par exemple un anticorps se liant de manière spécifique à EMAP II et placé dans un support acceptable sur le plan pharmacologique), ainsi que des techniques de criblage, utiles pour identifier des composés additionnels que l'on peut utiliser pour l'exécution desdits procédés.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)