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1. (WO2000029603) LOW COST MANUFACTURE OF OLIGOSACCHARIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/029603    International Application No.:    PCT/US1999/027599
Publication Date: 25.05.2000 International Filing Date: 18.11.1999
Chapter 2 Demand Filed:    16.06.2000    
IPC:
C12P 19/18 (2006.01)
Applicants: NEOSE TECHNOLOGIES, INC. [US/US]; 102 Witmer Road Horsham, PA 19044 (US) (For All Designated States Except US).
DEFREES, Shawn [US/US]; (US) (For US Only).
JOHNSON, Karl [US/US]; (US) (For US Only)
Inventors: DEFREES, Shawn; (US).
JOHNSON, Karl; (US)
Agent: SMITH, Timothy, L.; Townsend and Townsend and Crew LLP 8th floor Two Embarcadero Center San Francisco, CA 94111 (US)
Priority Data:
60/109,031 18.11.1998 US
60/109,096 19.11.1998 US
Title (EN) LOW COST MANUFACTURE OF OLIGOSACCHARIDES
(FR) PRODUCTION D'OLIGOSACCHARIDES BON MARCHE
Abstract: front page image
(EN)This invention provides recombinant cells, reaction mixtures, and methods that are useful for the enzymatic synthesis of product saccharides. The recombinant cells contain a heterologous gene that encodes a glycosyltransferase which catalyzes at least one step of the enzymatic synthesis, as well a system for generating a nucleotide sugar that can serve as a substrate for the glycosyltransferase. The recombinant cells, reaction mixtures, and methods are useful for efficiently synthesizing a large variety of saccharides, including polysaccharides, oligosaccharides, glycoproteins and glycolipids, using relatively low-cost starting materials.
(FR)L'invention concerne des cellules de recombinaison, des mélanges de réaction, et des techniques utilisées pour la synthèse enzymatique des saccharides de production. Les cellules de recombinaison contiennent un gène hétérologue codant pour une glycosyltransférase qui catalyse au moins une étape de la synthèse enzymatique, ainsi qu'un système permettant de produire un sucre de nucléotide pouvant servir de substrat à la glycosyltransférase. Ces cellules de recombinaison, ces mélanges de réaction, et ces techniques sont utilisés pour réaliser efficacement la synthèse d'une grande variété de saccharides, notamment des polysaccharides, des oligosaccharides, des glycoprotéines et des glycolipides, au moyen de produits de départ relativement bon marché.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)