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1. WO2000029598 - NOVEL RECOMBINANT ADENOVIRUS

Publication Number WO/2000/029598
Publication Date 25.05.2000
International Application No. PCT/JP1999/004902
International Filing Date 09.09.1999
Chapter 2 Demand Filed 21.12.1999
IPC
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C12N 15/861 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
861Adenoviral vectors
CPC
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 31/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
C12N 15/86
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
C12N 2710/10343
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2710dsDNA Viruses
00011dsDNA Viruses
10011Adenoviridae
10311Mastadenovirus, e.g. human or simian adenoviruses
10341Use of virus, viral particle or viral elements as a vector
10343viral genome or elements thereof as genetic vector
C12N 2800/30
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2800Nucleic acids vectors
30Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Applicants
  • SUMITOMO PHARMACEUTICALS COMPANY, LIMITED [JP]/[JP] (AllExceptUS)
  • SAITO, Izumu [JP]/[JP] (UsOnly)
  • KANEGAE, Yumi [JP]/[JP] (UsOnly)
Inventors
  • SAITO, Izumu
  • KANEGAE, Yumi
Agents
  • ASAMURA, Kiyoshi
Priority Data
10/32856618.11.1998JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) NOVEL RECOMBINANT ADENOVIRUS
(FR) NOUVEL ADENOVIRUS DE RECOMBINAISON
Abstract
(EN)
A recombinant adenovirus containing in its genome: (1) a left terminal inverted repeat sequence; (2) a packaging sequence; (3) a recombinase recognition sequence located between the left-terminal inverted repeat sequence and the packaging sequence; and (4) another recombinase recognition sequence recognized by a recombinase recognizing the above-described recombinase recognition sequence and located downstream of the packaging sequence; which is useful as a material for constructing a vector for gene therapy having a further elevated safety.
(FR)
L'invention porte sur un adénovirus de recombinaison qui contient dans son génome: (1) une séquence de répétition inversée terminale gauche; (2) une séquence d'encapsidation; (3) une séquence de reconnaissance de recombinase située entre la séquence de répétition inversée terminale gauche et la séquence d'encapsidation et (4) une autre séquence de reconnaissance de recombinase reconnue par une recombinase reconnaissant la séquence de reconnaissance de recombinase présentée ci-avant, et située en aval de la séquence d'encapsidation. Cet adénovirus de recombinaison est utile en tant que matériau de construction d'un vecteur destiné à la thérapie génique possédant un niveau de sécurité élevé.
Also published as
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