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Machine translation
1. (WO2000029584) ANTIBODY VARIANTS WITH HIGHER BINDING AFFINITY COMPARED TO PARENT ANTIBODIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/029584    International Application No.:    PCT/US1999/027153
Publication Date: 25.05.2000 International Filing Date: 16.11.1999
Chapter 2 Demand Filed:    15.05.2000    
IPC:
A61K 38/00 (2006.01), C07K 16/00 (2006.01), C07K 16/22 (2006.01), C07K 16/24 (2006.01)
Applicants: GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, CA 94080-4990 (US)
Inventors: CHEN, Yvonne, M.; (US).
LOWMAN, Henry, B.; (US).
MULLER, Yves; (DE)
Agent: WENDY, M., Lee; Genentech, Inc. 1 DNA Way South San Francisco, CA 94080-4990 (US).
KIDDLE, Simon and others Mewburn Ellis York House 23 Kingsway, London WC2B 6HP; 23 Kingsway, London WC2B 6HP (GB)
Priority Data:
60/108,945 18.11.1998 US
Title (EN) ANTIBODY VARIANTS WITH HIGHER BINDING AFFINITY COMPARED TO PARENT ANTIBODIES
(FR) VARIANTS D'ANTICORPS A AFFINITE DE LIAISON SUPERIEURE PAR RAPPORT AUX ANTICORPS D'ORIGINE
Abstract: front page image
(EN)Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen.
(FR)L'invention concerne des variants d'anticorps par rapport à des anticorps d'origine, caractérisés en ce qu'un ou plusieurs acides aminés sont insérés dans une région hypervariable de l'anticorps d'origine, et présentant une affinité de liaison vis-à-vis d'un antigène cible au moins deux fois plus forte que l'affinité de liaison de l'anticorps d'origine pour l'antigène considéré.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)