WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2000029577) NOVEL MEMBERS OF THE CAPSAICIN/VANILLOID RECEPTOR FAMILY OF PROTEINS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/029577    International Application No.:    PCT/US1999/026701
Publication Date: 25.05.2000 International Filing Date: 12.11.1999
Chapter 2 Demand Filed:    08.06.2000    
IPC:
C07K 14/705 (2006.01)
Applicants: MILLENNIUM PHARMACEUTICALS, INC. [US/US]; 75 Sidney Street, Cambridge, MA 02139 (US)
Inventors: CURTIS, Rory, A., J.; (US)
Agent: MANDRAGOURAS, Amy, E.; Lahive & Cockfield, LLP, 28 State Street, Boston, MA 02109 (US)
Priority Data:
60/108,322 13.11.1998 US
60/114,078 28.12.1998 US
09/258,633 26.02.1999 US
09/421,134 19.10.1999 US
Title (EN) NOVEL MEMBERS OF THE CAPSAICIN/VANILLOID RECEPTOR FAMILY OF PROTEINS AND USES THEREOF
(FR) NOUVEAUX ELEMENTS DE LA FAMILLE DE PROTEINES RECEPTRICES DE CAPSICINE/VANILLOIDE, ET UTILISATIONS DE CEUX-CI
Abstract: front page image
(EN)The invention provides isolated nucleic acids molecules, designated hVR-1, hVR-2, and rVR-2 nucleic acid molecules, which encode novel members of the Capsaicin/Vanilloid receptor family. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing hVR-1, hVR-2, and rVR-2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an hVR-1, hVR-2, and rVR-2 gene has been introduced or disrupted. The invention still further provides isolated hVR-1, hVR-2, and rVR-2 proteins, fusion proteins, antigenic peptides and anti-hVR-1, anti-hVR-2, and anti-rVR-2 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
(FR)L'invention concerne des nouvelles molécules d'acides nucléiques isolées, dénommées hVR-1, hVR-2 et rVR-2 et codant pour des nouveaux éléments de la famille réceptrice de capsicine/vanilloïde. L'invention concerne également de molécules d'acides nucléiques antisens, des vecteurs d'expression recombinés contenant les molécules d'acides nucléiques hVR-1, hVR-2 ou rVR-2, des cellules hôtes dans lesquelles on a introduit les vecteurs d'expression, ainsi que des animaux transgéniques, non humains, dans lesquels on a introduit ou dissocié le gène hVR-1, hVR-2 ou rVR-2. L'invention concerne encore des protéines isolées hVR-1, hVR-2, et rVR-2, des protéines de fusion, des peptides antigéniques et des anticorps dirigés contre hVR-1, hVR-2 et rVR-2, de même que des méthodes de diagnostic mettant en oeuvre les compositions de l'invention.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)