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Machine translation
1. (WO2000029434) PNEUMOCOCCAL CHOLINE BINDING PROTEINS, CbpG AND CbpD, DIAGNOSTIC AND THERAPEUTIC USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/029434    International Application No.:    PCT/US1999/027526
Publication Date: 25.05.2000 International Filing Date: 19.11.1999
Chapter 2 Demand Filed:    19.06.2000    
IPC:
A61K 38/00 (2006.01), A61K 39/00 (2006.01), C07K 14/315 (2006.01), C07K 16/12 (2006.01), G01N 33/569 (2006.01), G01N 33/68 (2006.01)
Applicants: ST. JUDE CHILDREN'S RESEARCH HOSPITAL [US/US]; 332 North Lauderdale Street Memphis, TN 38105-2794 (US) (AE, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CR, CU, CY, CZ, DE, DK, DM, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW only).
TUOMANEN, Elaine, I. [US/US]; (US) (For US Only).
GOSINK, Khoosheh [IR/US]; (US) (For US Only).
MASURE, Robert [US/US]; (US) (For US Only)
Inventors: TUOMANEN, Elaine, I.; (US).
GOSINK, Khoosheh; (US).
MASURE, Robert; (US)
Agent: DIETZEL, Christine, E.; Klauber & Jackson 411 Hackensack Avenue Hackensack, NJ 07601 (US)
Priority Data:
09/196,389 19.11.1998 US
09/443,553 18.11.1999 US
Title (EN) PNEUMOCOCCAL CHOLINE BINDING PROTEINS, CbpG AND CbpD, DIAGNOSTIC AND THERAPEUTIC USES THEREOF
(FR) IDENTIFICATION ET CARACTERISATION DE NOUVELLES PROTEINES PNEUMOCOCCIQUES SE LIANT A LA CHOLINE, CbpG AND CbpD, ET UTILISATIONS DIAGNOSTIQUES ET THERAPEUTIQUES CORRESPONDANTES
Abstract: front page image
(EN)The present invention provides isolated polypeptides comprising an amino acid sequence of a choline binding protein CbpG ou CbpD. This invention provides an isolated polypeptide comprising an amino acid sequence of a choline binding polypeptide CbpG or CbpD or N-terminal CbpG or CbpD truncate, including analogs, variants, mutants, derivatives and fragments thereof. This invention further provides an isolated immunogenic polypeptide comprising an amino acid sequence of a choline binding protein CbpG or CbpD. This invention provides an isolated nucleic acid encoding a polypeptide comprising an amino acid sequence of a choline binding protein CbpG or CbpD. This invention provides pharmaceutical compositions, vaccines, and disgnostic and therapeutic methods of use of the isolated polypeptides and nucleic acids. Assays for compounds which alter or inactivate the polypeptides of the present invention for use in therapy are also provided.
(FR)L'invention concerne des polypeptides isolés comprenant une séquence d'acide aminé d'une protéine CbpG ou CbpD se liant à la choline; un polypeptide isolé comprenant une séquence d'acide aminé d'une protéine CbpG ou CbpD ou CbpG à N-terminal ou CbpD tronquée se liant à la choline, y compris des analogues, des variantes, des mutants, des dérivés et des fragments correspondants; un polypeptide immunogène isolé comprenant une séquence d'acide aminé d'une protéine CbpG or CbpD se liant à la choline; un acide nucléique codant pour un polypeptide comprenant une séquence d'acide aminé d'une protéine CbpG or CbpD se liant à la choline; des compositions pharmaceutiques, des vaccins ainsi que des méthodes diagnostiques et thérapeutiques utilisant lesdits polypeptides isolés et acides nucléiques. L'invention concerne également des analyses destinées à des composés qui modifient ou inactivent les polypeptides selon l'invention à des fins thérapeutiques.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)