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Machine translation
1. (WO2000029413) PROCESS FOR PREPARING CROSS-BRIDGED TETRAAZA MACROCYCLES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/029413    International Application No.:    PCT/US1999/026540
Publication Date: 25.05.2000 International Filing Date: 09.11.1999
Chapter 2 Demand Filed:    18.05.2000    
IPC:
C07D 487/08 (2006.01)
Applicants: THE PROCTER & GAMBLE COMPANY [US/US]; One Procter & Gamble Plaza Cincinnati, OH 45202 (US) (For All Designated States Except US).
HILER, George, Douglas, II [US/US]; (US) (For US Only).
PERKINS, Christopher, Mark [US/US]; (US) (For US Only)
Inventors: HILER, George, Douglas, II; (US).
PERKINS, Christopher, Mark; (US)
Agent: REED, T., David; The Procter & Gamble Company 5299 Spring Grove Avenue Cincinnati, OH 45217-1087 (US)
Priority Data:
60/108,380 13.11.1998 US
Title (EN) PROCESS FOR PREPARING CROSS-BRIDGED TETRAAZA MACROCYCLES
(FR) PROCEDE DE PREPARATION DE MACROCYCLES TETRAAZA PONTES TRANSVERSALEMENT
Abstract: front page image
(EN)The present invention relates to a process for preparing a cross-bridged tetraaza macrocyclic ligands having formula (I), wherein each R is independently C¿1?-C¿22? linear alkyl, C¿1?-C¿22? branched alkyl, C¿7?-C¿22? alkylenearyl, C¿8?-C¿22? alkyl substituted alkylenearyl, and mixtures thereof; each index n is independently from 0 to 3, by contacting the a di-quaternary $i(cis) tetracycle precursor with as little as one equivalent of a borohydride reducing agent. The present process eliminates the need to use up to a twenty fold excess of reducing agent thereby further eliminating the need for work-up conditions which liberate significant amounts of hydrogen gas and which requires the disposal of large amounts of boron waste products.
(FR)L'invention concerne un procédé de préparation de ligands macrocycliques tétraaza pontés transversalement de formule (I); dans laquelle chaque R représente séparément un alkyle linéaire C¿1?-C¿22?, un alkyle ramifié C¿1?-C¿22?, un alkylènearyle C¿7?-C¿22?, un alkylènearyle substitué par un alkyle C¿8?-C¿22?, et leurs mélanges; chaque indice n va séparément de 0 à 3, par le contact du précurseur tétracycle $i(cis) di-quaternaire a, avec seulement un équivalent d'un agent réducteur borohydrure. Ledit procédé permet d'éliminer le besoin d'utiliser jusqu'à vingt fois plus d'agent réducteur, ainsi que des conditions de travail qui libèrent des quantités importantes de gaz d'hydrogène, ce qui nécessite l'élimination de grandes quantités de déchets de bore.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)