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1. WO2000029380 - TETRAHYDROISOQUINOLINE DERIVATIVES AS LHRH ANTAGONISTS

Publication Number WO/2000/029380
Publication Date 25.05.2000
International Application No. PCT/US1999/026584
International Filing Date 09.11.1999
Chapter 2 Demand Filed 02.06.2000
IPC
C07D 217/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
217Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
02with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
04with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
C07D 217/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
217Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
12with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
14other than aralkyl radicals
C07D 217/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
217Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
12with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
14other than aralkyl radicals
16substituted by oxygen atoms
C07D 217/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
217Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
12with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
18Aralkyl radicals
C07D 223/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
223Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
14condensed with carbocyclic rings or ring systems
16Benzazepines; Hydrogenated benzazepines
C07D 401/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
CPC
A61P 13/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
08of the prostate
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 5/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5Drugs for disorders of the endocrine system
C07D 217/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
217Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
02with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
04with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
C07D 217/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
217Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
12with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
14other than aralkyl radicals
Applicants
  • ABBOTT LABORATORIES [US]/[US]
Inventors
  • HAVIV, Fortuna
  • DWIGHT, Wesley, J.
  • CRAWFORD, Bradley, W.
  • SWENSON, Rolf, E.
  • BRUNCKO, Milan
  • KAMINSKI, Michele, A.
  • FREY, Lisa, M.
  • DEMATTEI, John
  • GREER, Jonathan
Agents
  • CHEN, Portia
Priority Data
09/151,51113.11.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TETRAHYDROISOQUINOLINE DERIVATIVES AS LHRH ANTAGONISTS
(FR) DERIVES DE TETRAHYDRO-ISOQUINOLEINE EN TANT QU'ANTAGONISTES LHRH
Abstract
(EN)
Tetrahydroisoquinoline derivatives of formula (I): or a pharmaceutically acceptable salt, ester, or prodrug thereof, having activity as an LHRH antagonist, as well as pharmaceutical compositions containing the same, and methods for their use and preparation.
(FR)
L'invention concerne des dérivés de tétrahydro-isoquinoléine de formule (I), ou un sel, un ester pharmaceutiquement acceptables, ou un promédicament de ces derniers, possédant une activité d'antagoniste LHRH, ainsi que des compositions pharmaceutiques les contenant, et des procédés de leur utilisation et préparation.
Latest bibliographic data on file with the International Bureau