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1. (WO2000029379) 1-AMINOETHYLQUINOLINE DERIVATIVES FOR TREATING URINARY INCONTINENCE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/029379    International Application No.:    PCT/FR1999/002760
Publication Date: 25.05.2000 International Filing Date: 10.11.1999
Chapter 2 Demand Filed:    05.06.2000    
IPC:
C07D 215/14 (2006.01), C07D 215/18 (2006.01), C07D 219/02 (2006.01)
Applicants: SANOFI-SYNTHELABO [FR/FR]; 174 avenue de France F-75013 Paris (FR) (For All Designated States Except US).
PHILIPPO, Christophe [FR/FR]; (FR) (For US Only).
MOUGENOT, Patrick [FR/FR]; (FR) (For US Only).
DEFOSSE, Gérard [FR/FR]; (FR) (For US Only).
BRAUN, Alain [FR/FR]; (FR) (For US Only).
BOVY, Philippe, R. [BE/FR]; (FR) (For US Only)
Inventors: PHILIPPO, Christophe; (FR).
MOUGENOT, Patrick; (FR).
DEFOSSE, Gérard; (FR).
BRAUN, Alain; (FR).
BOVY, Philippe, R.; (FR)
Agent: THOURET-LEMAITRE, Elisabeth; Sanofi-Synthelabo 174 avenue de France F-75013 Paris (FR)
Priority Data:
98/14398 17.11.1998 FR
Title (EN) 1-AMINOETHYLQUINOLINE DERIVATIVES FOR TREATING URINARY INCONTINENCE
(FR) DERIVES DE 1-AMINOETHYLQUINOLEINE POUR LE TRAITEMENT DE L'INCONTINENCE URINAIRE
Abstract: front page image
(EN)The invention concerns compounds of general formula (I) wherein: A represents a hydrogen atom, an azido, a halogen, a hydroxy, a thiol, an amino, a phenyl, a C¿1?-C¿6? alkyl, C¿1?-C¿6? alkylamino, di(C¿1?-C¿6? alkyl)amino, hydroxylamine, C¿1?-C¿6? alkyl hydroxylamine, N, O-C¿1?-C¿6? dialkyl hydroxylamine, C¿1?-C¿6? alkoxy or C¿1?-C¿6? alkylsulphanyl group; B and D represent independently of each other a hydrogen atom, a phenyl, a C¿1?-C¿6? alkyl, C¿2?-C¿6? alkenyl, C¿1?-C¿6? fluoroalkyl or C¿1?-C¿6? perfluoroalkyl group, or together form an oxo; R¿1? represents a hydrogen atom, a halogen, a carbonyl, a cyano, a carboxamide, a C¿1?-C¿6? alkyl, C¿2?-C¿6? alkenyl, C¿3?-C¿6? cycloalkyl, C¿1?-C¿6? alkoxycarbonyl, C¿1?-C¿6? hydroxyalkyl, C¿1?-C¿6? alkoxy, C¿1?-C¿6? alkoxy C¿1?-C¿6? alkyl, C¿1?-C¿6? fluoroalkyl, C¿1?-C¿2? perfluoroalkyl or CF¿3?(OH)CH group, or R¿1? and R¿2? together form, with the carbons whereto they are bound a phenyl; R¿5? and R¿6? represent, independently of each other, a hydrogen atom, a C¿1?-C¿6? alkyl, C¿2?-C¿6? alkenyl, C¿3?-C¿6? cycloalkyl, C¿3?-C¿6? cyloalkenyl, C¿1?-C¿6? fluoroalkyl, C¿1?-C¿2? perfluoroalkyl group or R¿5? and R¿6? together form a C¿2?-C¿6? alkylene, C¿3?-C¿6? alkenylene chain to produce with the nitrogen whereto they are bound a heterocycle, said heterocycle being optionally substituted by a C¿1?-C¿4? alkyl group. The invention has therapeutic applications.
(FR)Composés de formule générale (I) dans laquelle: A représente un atome d'hydrogène, un azido, un halogène, un hydroxy, un thiol, un amino, un phényle, un groupe C¿1-6? alkyle, C¿1-6? alkylamino, di(C¿1-6? alkyl) amino, hydroxylamine, C¿1-6? alkyl hydroxylamine, N,O-C¿1-6? dialkyl hydroxylamine, C¿1-6? alcoxy ou C¿2-6? alkylsulfanyle, B et D représentent, indépendamment l'un de l'autre, un atome d'hydrogène, un phényle, un groupe C¿2-6? alkyle, C¿1-6? alkényle, C¿1-6? fluoroalkyle ou C¿1-2? perfluoroalkyle, ou ensemble forment un oxo, R¿1? représente un atome d'hydrogène, un halogène, un carbonyle, un hydroxycarbonyle, un cyano, un carboxamide, un groupe C¿1-6? alkyle, C¿2-6? alkényle, C¿3-6? cycloalkyle, C¿1-6? alcoxycarbonyle, C¿1-6? hydroxyalkyle, C¿1-6? alcoxy, C¿1-6? alcoxy C¿1-3? alkyle, C¿1-6? fluoroalkyle, C¿1-2? perfluoroalkyle ou CF¿3?(OH)CH, ou R¿1? et R¿2?, ensemble, forment une chaîne C¿3-5? alkylène, C¿3-5? alkénylène ou forment, avec les carbones auxquels ils ont rattachés, un phényle, R¿5? et R¿6? représentent, indépendamment l'un de l'autre, un atome d'hydrogène, un groupe C¿1-6? alkyle, C¿2-6? alkényle, C¿3-6? cycloalkyle, C¿3-6? cycloalkényle, C¿1-6? fluoroalkyle, C¿1-2? perfluoroalkyle ou R¿5? et R¿6?, ensemble, forment une chaîne C¿2-6? alkylène, C¿3-6? alkénylène pour donner avec l'azote auquel ils sont rattachés un hétérocycle, cet hétérocylce étant éventuellement substitué par un groupe C¿1-4? alkyle. Application en thérapeutique.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: French (FR)
Filing Language: French (FR)