WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2000029376) HETEROARYLTHIO COMPOUNDS AND CANCER REMEDIES CONTAINING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/029376    International Application No.:    PCT/JP1999/006420
Publication Date: 25.05.2000 International Filing Date: 17.11.1999
Chapter 2 Demand Filed:    17.11.1999    
IPC:
C07D 207/12 (2006.01)
Applicants: KYOWA HAKKO KOGYO CO., LTD. [JP/JP]; 6-1, Otemachi 1-chome Chiyoda-ku, Tokyo 100-8185 (JP) (For All Designated States Except US).
FUJI PHOTO FILM CO., LTD. [JP/JP]; No. 210 Nakanuma Minami-ashigara-shi, Kanagawa 250-0193 (JP) (For All Designated States Except US).
TAMAOKI, Tatsuya [JP/JP]; (JP) (For US Only).
TAKAHASHI, Takeshi [JP/JP]; (JP) (For US Only).
MIZUKAMI, Tamio [JP/JP]; (JP) (For US Only).
KANDA, Yuko [JP/JP]; (JP) (For US Only).
KAWAKAMI, Masayuki [JP/JP]; (JP) (For US Only).
TAKAHASHI, Kazunobu [JP/JP]; (JP) (For US Only).
YAN, Yongzhe [CN/JP]; (JP) (For US Only)
Inventors: TAMAOKI, Tatsuya; (JP).
TAKAHASHI, Takeshi; (JP).
MIZUKAMI, Tamio; (JP).
KANDA, Yuko; (JP).
KAWAKAMI, Masayuki; (JP).
TAKAHASHI, Kazunobu; (JP).
YAN, Yongzhe; (JP)
Agent: IMAMURA, Masazumi; 5th floor, KRF Building 5-5, Kyobashi 1-chome Chuo-ku Tokyo 104-0031 (JP)
Priority Data:
10/326450 17.11.1998 JP
Title (EN) HETEROARYLTHIO COMPOUNDS AND CANCER REMEDIES CONTAINING THE SAME
(FR) COMPOSES HETEROARYLTHIO ET MEDICAMENTS CONTRE LE CANCER CONTENANT LESDITS COMPOSES
Abstract: front page image
(EN)Compounds represented by the following general formula (I) Ar?1¿-S-R?1¿-S-Ar?2¿, and salts thereof, which have an effect of inhibiting ribonucleotide reductase to suppress the proliferation of cancer cells selectively wherein Ar?1¿ is aryl bearing 1 to 3 hydroxyl groups on the ring; Ar?2¿ is monocyclic heteroaryl containing as the ring-constituting atoms 1 to 3 heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur and optionally bearing a substituent on the ring; and R?1¿ is -R?2¿-X?1¿-R?3¿- [wherein R?2¿ and R?3¿ are each independently an optionally substituted C¿1?-C¿10? carbon chain; and X?1¿ is CH¿2?, O or N(R?4¿) (wherein R?4¿ is a monovalent group or a monovalent atom)].
(FR)Composés de formule générale Ar?1¿-S-R?1¿-S-Ar?2¿, et sels desdits composés, qui possèdent un effet d'inhibition de la ribonucléotide réductase pour supprimer sélectivement la prolifération de cellules cancéreuses. Dans ladite formule, Ar?1¿ est aryle portant 1 à 3 groupes hydroxyle sur le noyau, Ar?2¿ est hétéroaryle monocyclique contenant, en tant qu'atomes constituant le noyau, un à trois hétéroatomes choisis dans le groupe constitué par oxygène, azote et soufre, et portant éventuellement un substituant sur le noyau, et R?1¿ est -R?2¿-X?1¿-R?3¿- (R?2¿ et R?3¿ étant chacun indépendammentne chaîne carbone C¿1?-C¿10? éventuellement substituée, et X?1¿ étant CH¿2?, O ou N(R?4¿), R?4¿ étant un groupe monovalent ou un atome monovalent).
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)