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1. (WO2000029375) BISARYL COMPOUNDS AND CANCER REMEDIES CONTAINING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/029375    International Application No.:    PCT/JP1999/006419
Publication Date: 25.05.2000 International Filing Date: 17.11.1999
Chapter 2 Demand Filed:    17.11.1999    
IPC:
C07D 207/12 (2006.01), C07D 493/04 (2006.01)
Applicants: KYOWA HAKKO KOGYO CO., LTD. [JP/JP]; 6-1, Otemachi 1-chome Chiyoda-ku, Tokyo 100-8185 (JP) (For All Designated States Except US).
FUJI PHOTO FILM CO., LTD. [JP/JP]; No.210 Nakanuma Minami-ashigara-shi, Kanagawa 250-0193 (JP) (For All Designated States Except US).
TAMAOKI, Tatsuya [JP/JP]; (JP) (For US Only).
TAKAHASHI, Takeshi [JP/JP]; (JP) (For US Only).
MIZUKAMI, Tamio [JP/JP]; (JP) (For US Only).
IKEDA, Shun-ichi [JP/JP]; (JP) (For US Only).
KANDA, Yuko [JP/JP]; (JP) (For US Only).
IKEGAWA, Akihiko [JP/JP]; (JP) (For US Only).
YAN, Yongzhe [CN/JP]; (JP) (For US Only)
Inventors: TAMAOKI, Tatsuya; (JP).
TAKAHASHI, Takeshi; (JP).
MIZUKAMI, Tamio; (JP).
IKEDA, Shun-ichi; (JP).
KANDA, Yuko; (JP).
IKEGAWA, Akihiko; (JP).
YAN, Yongzhe; (JP)
Agent: IMAMURA, Masazumi; 5th floor, KRF Building 5-5, Kyobashi 1-chome Chuo-ku Tokyo 104-0031 (JP)
Priority Data:
10/326449 17.11.1998 JP
Title (EN) BISARYL COMPOUNDS AND CANCER REMEDIES CONTAINING THE SAME
(FR) COMPOSES BYSARYLE ET MEDICAMENTS CONTRE LE CANCER CONTENANT LESDITS COMPOSES
Abstract: front page image
(EN)Compounds represented by the general formula (I), and salts thereof, which have an effect of inhibiting ribonucleotide reductase to suppress the proliferation of cancer cells selectively: Ar?1¿-S-R?1¿-S-Ar?2¿ wherein R?1¿ is a monocyclic connecting group which has one saturated five-membered cyclic structure containing one or more nitrogen atoms as the ring-constituting atoms, or a bi- or tricyclic connecting group which has two or three saturated five- or six-membered cyclic structures and contains as the ring-constituting atoms one or more heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur; and Ar?1¿ and Ar?2¿ are each an aryl or heteroaryl group having one or more hydroxyl groups on the ring.
(FR)Composés de formule générale Ar?1¿-S-R?1¿-S-AR?2¿, et sels desdits composés, qui possèdent un effet d'inhibition de la ribonucléotide réductase pour supprimer sélectivement la prolifération de cellules cancéreuses. Dans ladite formule, R?1¿ est un groupe de liaison monocyclique qui possède une structure cyclique saturée à cinq éléments contenant un ou plusieurs atomes d'azote en tant qu'atomes constituant le noyau, ou un groupe de liaison bicyclique ou tricyclique qui possède deux ou trois structures cycliques saturées à cinq ou six éléments et contient, en tant qu'atomes constituant le noyau, un ou plusieurs hétéroatomes choisis dans le groupe constitué par azote, oxygène et soufre, et Ar?1¿ et Ar?2¿ sont chacun un groupe aryle ou hétéroaryle ayant un ou plusieurs groupes hydroxyle sur le noyau.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)