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1. WO2000028329 - SCREENING TEST FOR EARLY DETECTION OF COLORECTAL CANCER

Publication Number WO/2000/028329
Publication Date 18.05.2000
International Application No. PCT/CA1999/001034
International Filing Date 03.11.1999
Chapter 2 Demand Filed 01.04.2000
IPC
G01N 33/574 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
CPC
G01N 33/57419
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
57407Specifically defined cancers
57419of colon
G01N 33/57446
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
57407Specifically defined cancers
57446of stomach or intestine
G01N 33/57484
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
57484involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
Applicants
  • KREPINSKY, Jiri, J. [CA]/[CA]
Inventors
  • KREPINSKY, Jiri, J.
  • CHOCIEJ, Jacek
Agents
  • SMITH, LYONS
Priority Data
09/270,10316.03.1999US
2,253,09306.11.1998CA
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SCREENING TEST FOR EARLY DETECTION OF COLORECTAL CANCER
(FR) TEST DE DEPISTAGE PERMETTANT UN DEPISTAGE PRECOCE DU CANCER COLORECTAL
Abstract
(EN)
A method for detecting neoplasia or cancer of the colon or rectum comprising obtaining a sample of colorectal mucus from the rectum of a patient, and detecting the presence of a marker selected from the group consisting of long chain aliphatic aldehydes containing 12 - 20 carbon atoms, particularly CH3(CH2)14CHO and CH3(CH2)16CHO; and plasmalogen-bound precursors thereof. Preferably the method comprises treating the sample with Schiff's Reagent and detecting neoplasia or cancer of the colon or rectum based upon the coloration produced at about 550 - 590 nm in the sample by the treatment. The method does not require the step of adding an enzyme for detecting the disaccharide marker $g(b)-D-Gal(1-3)-D-GalNAc($g(a)1-Thr/Ser) and a saccharide marker containing D-galactose and/or 2-acetamido-2-deoxy-D-galactose.
(FR)
L'invention se rapporte à un procédé permettant de déceler une néoplasie ou de dépister le cancer du colon ou du rectum. Ce procédé consiste à prélever un échantillon de mucus colorectal du rectum d'un patient, et à déceler la présence d'un marqueur sélectionné dans le groupe constitué d'aldéhydes aliphatiques à longue chaîne contenant 12 à 20 atomes de carbone, notamment CH3(CH2)14CHO et CH3(CH2)16CHO; et de précurseurs, liés au plasmalogène, de ce marqueur. De préférence, le procédé consiste à traiter le prélèvement avec un réactif de Schiff et à déceler la néoplasie ou à dépister le cancer du colon ou du rectum en fonction de la coloration produite dans le prélèvement par le traitement à environ 550-590 nm. Ce procédé ne requiert aucune addition d'enzyme permettant de détecter le marqueur disaccharide $g(b)-D-Gal(1-3)-D-GalNAc($g(a)1-Thr/Ser) et un marqueur saccharide contenant du D-galactose et/ou du 2-acétamido-2-désoxy-D-galactose.
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