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Machine translation
1. (WO2000028071) A METHOD FOR THE DETERMINATION OF HOMOCYSTEINE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/028071    International Application No.:    PCT/US1999/026989
Publication Date: 18.05.2000 International Filing Date: 12.11.1999
Chapter 2 Demand Filed:    29.05.2000    
IPC:
C12Q 1/527 (2006.01), G01N 33/68 (2006.01)
Applicants: GENZYME CORPORATION [US/US]; 15 Pleasant Street Connector P.O. Box 9322 Framingham, MA 01701-9322 (US)
Inventors: SEMAN, Leo; (US)
Agent: TEGFELDT, Jennifer; Genzyme Corporation 15 Pleasant Street Connector P.O. Box 9322 Framingham, MA 01701-9322 (US).
DUPRE, Jennifer, A.; Genzyme Corporartion Metrowest Place 15 Pleasent Street Connector P.O. Box 9322 Framingham, MA 01701-9322 (US)
Priority Data:
60/108,099 12.11.1998 US
Title (EN) A METHOD FOR THE DETERMINATION OF HOMOCYSTEINE
(FR) METHODE DE DETERMINATION D'HOMOCYSTEINE
Abstract: front page image
(EN)The invention relates to a method for determining homocysteine concentration in samples in which homocysteine is condensed using an enzyme cystathionine $g(b) synthase to form cystathionine. Pyruvate and/or ammonia are released from cystathionine by action of an enzyme, cystathionine $g(b) lyase, and homocysteine is regenerated. The release of pyruvate and/or ammonia can be correlated to the concentration of homocysteine present in the sample.
(FR)L'invention concerne une méthode de détermination de la concentration d'homocystéine dans des échantillons dans lesquels l'homocystéine est condensée au moyen d'un enzyme, la cystathionine $g(b) synthase, pour former de la cystathionine. Le pyruvate et/ou l'ammoniac sont libérés de la cystathionine par l'action d'un enzyme, la cystathionine $g(b) lyase, puis l'homocystéine est régénéré. La libération du pyruvate et/ou de l'ammoniac peut être corrélée à la concentration d'homocystéine présente dans l'échantillon.
Designated States: AU, CA, JP.
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)