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Machine translation
1. (WO2000027871) NEW FAMILY OF MAMMALIAN POTASSIUM CHANNELS, THEIR CLONING AND THEIR USE, ESPECIALLY FOR THE SCREENING OF DRUGS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/027871    International Application No.:    PCT/IB1999/001886
Publication Date: 18.05.2000 International Filing Date: 09.11.1999
Chapter 2 Demand Filed:    24.05.2000    
IPC:
C07K 14/705 (2006.01)
Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS [FR/FR]; 3, rue Michel Ange, F-75794 Paris Cedex 16 (FR)
Inventors: DUPRAT, Fabrice; (FR).
LESAGE, Florian; (FR).
LAZDUNSKI, Michel; (FR)
Agent: BREESE-MAJEROWICZ; 3, avenue de l'Opéra, F-75001 Paris (FR)
Priority Data:
60/107,692 09.11.1998 US
09/436,265 08.11.1999 US
Title (EN) NEW FAMILY OF MAMMALIAN POTASSIUM CHANNELS, THEIR CLONING AND THEIR USE, ESPECIALLY FOR THE SCREENING OF DRUGS
(FR) NOUVELLE FAMILLE DE CANAUX POTASSIQUES DE MAMMIFERES, LEURS CLONAGE ET LEUR APPLICATION, SPECIALEMENT DANS LE CRIBLAGE DE MEDICAMENTS
Abstract: front page image
(EN)This invention relates to a new member of a recently recognized TWIK potassium transport channels, herein designated as TASK2. TASK2 is a unique potassium transport channel which is regulated by external pH and predominantly expressed in kidney and epithelial tissues. The invention relates to various constructs of TASK2 for the production of TASK2 and their uses for diagnostic tests and screening methods to identify compounds that modulate potassium transport.
(FR)L'invention concerne un nouveau membre des canaux de transport de potassium TWIK récemment identifiés, appelés TASK2. TASK2 est un canal de transport d'un seul potassium régulé par un pH externe et exprimé essentiellement dans les tissus épithéliaux et rénaux. L'invention concerne aussi différentes constructions de TASK2 en vue de la production TASK2 et leurs application dans les tests diagnostiques et les procédés de criblage permettant d'identifier les composés qui modulent le transport de potassium.
Designated States: CA, JP.
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)