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Machine translation
1. (WO2000027846) CRF RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/027846    International Application No.:    PCT/US1999/027054
Publication Date: 18.05.2000 International Filing Date: 12.11.1999
Chapter 2 Demand Filed:    09.06.2000    
IPC:
C07D 471/16 (2006.01), C07D 487/16 (2006.01)
Applicants: NEUROCRINE BIOSCIENCES, INC. [US/US]; 10555 Science Center Drive San Diego, CA 92121 (US) (For All Designated States Except US).
HADDACH, Mustapha [MA/US]; (US) (For US Only).
NELSON, Jodie [US/US]; (US) (For US Only).
DYCK, Brian, P. [CA/US]; (US) (For US Only).
GUO, Zhiqiang [CN/US]; (US) (For US Only).
HUANG, Charles, Q. [CN/US]; (US) (For US Only).
MCCARTHY, James, R. [US/US]; (US) (For US Only)
Inventors: HADDACH, Mustapha; (US).
NELSON, Jodie; (US).
DYCK, Brian, P.; (US).
GUO, Zhiqiang; (US).
HUANG, Charles, Q.; (US).
MCCARTHY, James, R.; (US)
Agent: HERMANNS, Karl, R.; Seed and Berry LLP 6300 Columbia Center 701 Fifth Avenue Seattle, WA 98104-7092 (US).
GOWSHALL, Jonathan V. FORRESTER & BOEHMERT; Forrester & Boehmert Franz-Joseph-Str. 38 D-80801 München (DE)
Priority Data:
09/191,073 12.11.1998 US
09/370,837 09.08.1999 US
09/401,364 21.09.1999 US
Title (EN) CRF RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO
(FR) ANTAGONISTES DE RECEPTEURS DU CRF ET METHODES ASSOCIEES
Abstract: front page image
(EN)CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke. The CRF receptor antagonists of this invention have structure (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein n, m, A, B, C, R, R¿1?, R¿2? and Ar are as defined herein. Compositions containing a CRF receptor antagonist in combination with a pharmaceutically acceptable carrier are also disclosed, as well as methods for use of the same.
(FR)L'invention concerne des antagonistes de récepteurs du CRF, qui sont utiles dans le traitement de diverses affections, notamment dans le traitement d'affections dans lesquelles on observe une hypersécrétion de CRF chez les animaux à sang chaud, en particulier les accidents vasculaires cérébraux. Les antagonistes de récepteurs du CRF de l'invention présentent la structure de la formule (I), dans laquelle n, m, A, B, C, R, R¿1?, R¿2?, et Ar sont tels que définis dans le descriptif, y compris leurs stéréoisomères et leurs sels acceptables sur le plan pharmaceutique. L'invention concerne également des compositions contenant un antagoniste de récepteur du CRF en combinaison avec un excipient acceptable sur le plan pharmaceutique, ainsi que des méthodes d'utilisation de ces compositions.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)