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1. WO2000027844 - PROCESS FOR THE PREPARATION OF PAROXETINE HYDROCHLORIDE

Publication Number WO/2000/027844
Publication Date 18.05.2000
International Application No. PCT/GB1999/003664
International Filing Date 05.11.1999
Chapter 2 Demand Filed 16.05.2000
IPC
A61K 9/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
C07D 405/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
A61K 9/1688
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1682Processes
1688resulting in pure drug agglomerate optionally containing up to 5% of excipient
C07D 405/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Y02P 20/54
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
20Technologies relating to chemical industry
50Improvements relating to the production of bulk chemicals
54using solvents, e.g. supercritical solvents or ionic liquids
Applicants
  • SMITHKLINE BEECHAM PLC [GB]/[GB] (AllExceptUS)
  • CAMBURN, Ian, David [GB]/[GB] (UsOnly)
  • MERRIFIELD, David, Roy [GB]/[GB] (UsOnly)
  • VALDER, Christopher, Edmund [GB]/[GB] (UsOnly)
Inventors
  • CAMBURN, Ian, David
  • MERRIFIELD, David, Roy
  • VALDER, Christopher, Edmund
Agents
  • WEST, Vivien
Priority Data
9824298.505.11.1998GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR THE PREPARATION OF PAROXETINE HYDROCHLORIDE
(FR) PROCEDE DE PREPARATION DE CHLORHYDRATE DE PAROXETINE
Abstract
(EN)
Solid forms of paroxetine hydrochloride (crystalline as well as amorphous) are obtained by precipitation from a supercritical or near-critical fluid such as carbon dioxide. This procedure offers the advantage of a more easily controlled precipitation process than is obtained by previously known methods, and better control of surface morphology, porosity, particle size and distribution.
(FR)
On obtient des formes solides de chlorhydrate de paroxétine (cristallin et amorphe) par précipitation à partir d'un fluide supercritique ou presque critique tel que le dioxyde de carbone. Cette procédure offre l'avantage d'un processus de précipitation plus facilement régulé par rapport à des procédés antérieurement connus, et une meilleure régulation de la morphologie de surface, de la porosité, de la grosseur et de la répartition des particules.
Also published as
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