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1. (WO2000027842) COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/027842    International Application No.:    PCT/SE1999/001988
Publication Date: 18.05.2000 International Filing Date: 03.11.1999
Chapter 2 Demand Filed:    18.05.2000    
C07D 213/75 (2006.01), C07D 401/12 (2006.01), C07D 401/14 (2006.01), C07D 405/14 (2006.01), C07D 409/14 (2006.01), C07D 413/14 (2006.01), C07D 417/14 (2006.01)
Applicants: ASTRAZENECA AB [SE/SE]; S-151 85 Södertälje (SE) (For All Designated States Except US).
COOK, Anthony [GB/GB]; (GB) (For US Only).
HAMLEY, Peter [GB/GB]; (GB) (For US Only).
TINKER, Alan [GB/GB]; (GB) (For US Only)
Inventors: COOK, Anthony; (GB).
HAMLEY, Peter; (GB).
TINKER, Alan; (GB)
Agent: ASTRAZENECA; Global Intellectual Property P.O. Box 272 Mereside, Alderley Park Macclesfield Cheshire, SK10 4GR (GB)
Priority Data:
9803773-2 05.11.1998 SE
Abstract: front page image
(EN)There are provided novel compounds of formula (I) wherein R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, A, Q, X, Y, and Z are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and tautomers thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.
(FR)L'invention concerne: de nouveaux composés de la formule (I), dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, A, Q, X, Y et Z sont définis dans les pièces descriptives de la demande ; et des sels pharmaceutiquement acceptables de ces derniers ; des énantiomères et des tautomères de ces derniers ; des procédés pour les préparer, des compositions les contenant et leur utilisation à des fins thérapeutiques. Ces composés sont des inhibiteurs de l'oxyde nitrique synthase et sont de ce fait, particulièrement utiles dans le traitement ou la prévention de maladies inflammatoires et de la douleur.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)