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1. (WO2000027811) NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/027811    International Application No.:    PCT/US1999/026798
Publication Date: 18.05.2000 International Filing Date: 09.11.1999
Chapter 2 Demand Filed:    02.06.2000    
IPC:
C07D 207/08 (2006.01), C07D 401/12 (2006.01), C07D 403/12 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; P.O. Box 4000 Princeton, NJ 08543-4000 (US)
Inventors: DUBOWCHIK, Gene, M.; (US).
DITTA, Jonathan, L.; (US).
PROVENCAL, David, P.; (US).
DENHART, Derek, J.; (US)
Agent: DUBOFF, Samuel, J.; Bristol-Myers Squibb Company 5 Research Parkway Wallingford, CT 06492-7660 (US)
Priority Data:
60/108,060 12.11.1998 US
Title (EN) NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS
(FR) AGENTS NEUROTROPHIQUES DE DIAMIDE ET CARBAMATE
Abstract: front page image
(EN)The present invention relates to the design, synthesis, and the peptidyl-prolyl isomerase (PPIase or rotamase) inhibitory activity of novel pyrrolidinemethyl diamide and carbamate compounds that are neurotrophic agents (i.e. compounds capable of stimulating growth or proliferation of nervous tissue) and that bind to immunophilins such as FKBP12 and inhibit their rotamase activity. This invention also relates to pharmaceutical compositions comprising these compounds.
(FR)La présente invention porte sur la formation, la synthèse et l'activité inhibitrice de peptidyl-prolyl isomérase (PPIase ou rotamase) de nouveaux composés pyrrolidineméthyl de diamide et de carbamate qui sont des agents neutrophiques (c.-à-d. des composés capables de stimuler la croissance ou la prolifération du tissu nerveux) et qui se fixent aux immunophilines telles que FKBP12 et inhibent l'activité de leur rotamase. Cette invention porte également sur des compositions pharmaceutiques comprenant ces composés.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)