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Machine translation
1. (WO2000027803) CYSTEINE AMIDES AS FARNESYL TRANSFERASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/027803    International Application No.:    PCT/DE1999/003562
Publication Date: 18.05.2000 International Filing Date: 04.11.1999
IPC:
C07C 233/44 (2006.01), C07C 237/22 (2006.01), C07C 323/60 (2006.01)
Applicants: JOMAA, Hassan [DE/DE]; (DE) (For All Designated States Except US).
SCHLITZER, Martin [DE/DE]; (DE) (For US Only).
SAKOWSKI, Jacek [DE/DE]; (DE) (For US Only).
SATTLER, Isabel [DE/DE]; (DE) (For US Only).
GRABLEY, Susanne [DE/DE]; (DE) (For US Only).
THIERICKE, Ralf [DE/DE]; (DE) (For US Only)
Inventors: SCHLITZER, Martin; (DE).
SAKOWSKI, Jacek; (DE).
SATTLER, Isabel; (DE).
GRABLEY, Susanne; (DE).
THIERICKE, Ralf; (DE)
Priority Data:
198 51 714.9 05.11.1998 DE
Title (DE) AMIDE DES CYSTEINS ALS INHIBITOREN DER FARNESYLTRANSFERASE
(EN) CYSTEINE AMIDES AS FARNESYL TRANSFERASE INHIBITORS
(FR) AMIDES DE LA CYSTEINE COMME INHIBITEURS DE LA FARNESYLTRANSFERASE
Abstract: front page image
(DE)Die Erfindung betrifft Verbindungen der Formel (I) mit inhibitorischen Wirkungen auf die Farnesyltransferase. Einige dieser Verbindungen zeigen eine in vitro Hemmung der Farnesyltransferase bei Konzentrationen < 1 $g(m)M. Die erfindungsgemäßen Verbindungen haben die allgemeine Formel (I), worin n = 0 - 3; R?1¿, R?2¿ = H, Alkyl, Aryl, Heteroaryl, Acyl; R?3¿ = H, Halogen, Alkyl, Aryl, Heteroaryl, Arylalkyl, Acyl, CN, NO¿2?, R?4¿-X-; R?4¿ = H, Alkyl, Aryl, Heteroaryl, Aralkyl, Acyl; X = NH, O, S, SO¿2?, NHSO¿2?, OSO¿2?, und A, B, C = organische Reste sind.
(EN)The invention relates to compounds of formula (I) which have inhibitory effects on farnesyl transferase. Some of these compounds present in vitro inhibition of farnesyl transferase at concentrations < 1 $g(m)M. The compounds provided for in the invention have the general formula (I), in which n is between 0 and 3; R?1¿, R?2¿ are H, alkyl, aryl, heteroaryl, acyl; R?3¿ is H, halogen, alkyl, aryl, heteroaryl, arylalkyl, acyl, CN, NO¿2?, R?4¿-X-; R?4¿ is H, alkyl, aryl, heteroaryl, aralkyl, acyl; X is NH, O, S, SO¿2?, NHSO¿2?, OSO¿2?; and A, B, C are organic rests.
(FR)L'invention concerne des composés de formule (I) ayant des effets inhibiteurs sur la farnésyltransférase. Quelques-uns de ces composés présentent une inhibition in vitro de la farnésyltransférase pour des concentrations inférieures à 1 $g(m)M. Les composés selon l'invention ont la formule générale (I), dans laquelle n vaut 0 à 3, R?1¿ et R?2¿ représentent H, alkyle, aryle, hétéroaryle, acyle, R?3¿ représente H, halogène, alkyle, aryle, hétéroaryle, arylalkyle, acyle, CN, NO¿2?, R?4¿-X-, R?4¿ représente H, alkyle, aryle, hétéroaryle, arylalkyle, acyle, X représente NH, O, S, SO¿2?, NHSO¿2?, OSO¿2? et A, B, C sont des restes organiques.
Designated States: AE, AL, AU, BA, BB, BG, BR, CA, CN, CU, CZ, DE, EE, GD, GE, HR, HU, ID, IL, IN, IS, JP, KP, KR, LC, LK, LR, LT, LV, MG, MK, MN, MX, NO, NZ, PL, RO, SG, SI, SK, TR, TT, UA, US, UZ, VN, YU, ZA.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: German (DE)
Filing Language: German (DE)