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1. WO2000027496 - A CHROMATOGRAPHY METHOD AND A COLUMN MATERIAL USEFUL IN SAID METHOD

Publication Number WO/2000/027496
Publication Date 18.05.2000
International Application No. PCT/SE1999/002032
International Filing Date 09.11.1999
Chapter 2 Demand Filed 30.05.2000
IPC
B01D 15/08 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
08Selective adsorption, e.g. chromatography
B01D 15/36 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
08Selective adsorption, e.g. chromatography
26characterised by the separation mechanism
36involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
B01J 20/32 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
20Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
30Processes for preparing, regenerating or reactivating
32Impregnating or coating
B01J 39/26 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
39Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
26Cation exchangers for chromatographic processes
B01J 43/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
43Amphoteric ion-exchange, i.e. using ion-exchangers having cationic and anionic groups; Use of material as amphoteric ion-exchangers; Treatment of material for improving their amphoteric ion-exchange properties
G01N 30/52 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
50Conditioning of the sorbent material or stationary liquid
52Physical parameters
CPC
B01D 15/364
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
26characterised by the separation mechanism
36involving ionic interaction
361Ion-exchange
364Amphoteric or zwitterionic ion-exchanger
B01J 20/28078
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
20Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
28characterised by their form or physical properties
28054characterised by their surface properties or porosity
28078Pore diameter
B01J 20/286
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
20Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
281Sorbents specially adapted for preparative, analytical or investigative chromatography
286Phases chemically bonded to a substrate, e.g. to silica or to polymers
B01J 20/289
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
20Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
281Sorbents specially adapted for preparative, analytical or investigative chromatography
286Phases chemically bonded to a substrate, e.g. to silica or to polymers
289bonded via a spacer
B01J 20/3092
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
20Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
30Processes for preparing, regenerating, or reactivating
3092Packing of a container, e.g. packing a cartridge or column
B01J 20/321
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
20Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
30Processes for preparing, regenerating, or reactivating
32Impregnating or coating ; ; Solid sorbent compositions obtained from processes involving impregnating or coating
3202characterised by the carrier, support or substrate used for impregnation or coating
3206Organic carriers, supports or substrates
3208Polymeric carriers, supports or substrates
321consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
Applicants
  • IRGUM, Knut [SE]/[SE]
  • VIKLUND, Camilla [SE]/[SE]
Inventors
  • IRGUM, Knut
  • VIKLUND, Camilla
Agents
  • BERG, S. A.
Priority Data
9803838-309.11.1998SE
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A CHROMATOGRAPHY METHOD AND A COLUMN MATERIAL USEFUL IN SAID METHOD
(FR) PROCEDE DE CHROMATOGRAPHIE, ET SUBSTANCE DE GARNITURE DE LA COLONNE UTILISEE DANS LE CADRE DUDIT PROCEDE
Abstract
(EN)
The present invention relates to a novel sorbent suitable for use as a stationary phase in a chromatography column, the core of which consists of an organic polymer of synthetic or natural origin. Further, the carrier according to the invention exhibits a plurality of covalently bonded non-aromatic zwitterionic groups on its surface. Additionally, the invention also relates to a method for purifying a particular biological macromolecule, such as a protein or a nucleic acid, by zwitterionic ion exchange chromatography as well as an ion exchange column suitable for use in zwitterionic ion exchange chromatography.
(FR)
La présente invention concerne un nouveau sorbant pouvant être utilisé comme phase stationnaire dans une colonne de chromatographie, dont la partie centrale est constituée d'un polymère organique d'origine naturelle ou synthétique. En outre, le support selon l'invention comporte en surface une pluralité de groupes zwittérioniques non aromatiques à liaison covalente. L'invention concerne également un procédé de purification d'une macromolécule biologique spécifique, telle qu'une protéine ou un acide nucléique, par chromatographie par échange d'ions zwittérioniques, ainsi qu'une colonne échangeuse d'ions pouvant être utilisée en chromatographie par échange d'ions zwittérioniques.
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