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Machine translation
1. (WO2000027423) METHODS AND COMPOSITIONS FOR TREATING COMMON COLD SYMPTOMS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/027423    International Application No.:    PCT/US1999/027003
Publication Date: 18.05.2000 International Filing Date: 12.11.1999
Chapter 2 Demand Filed:    09.06.2000    
IPC:
A61K 31/00 (2006.01), A61K 31/285 (2006.01), A61K 31/33 (2006.01), A61K 38/41 (2006.01), C12Q 1/18 (2006.01), G01N 33/50 (2006.01), G01N 33/68 (2006.01)
Applicants: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT [US/US]; 141 MUSC Complex Suite 305 Cannon Park Place Charleston, SC 29425 (US) (For All Designated States Except US).
TURNER, Ronald, B. [US/US]; (US) (For US Only)
Inventors: TURNER, Ronald, B.; (US)
Agent: SPRATT, Gwendolyn, D.; Needle & Rosenberg, P.C. Suite 1200 The Candler Building 127 Peachtree Street, N.E. Atlanta, GA 30303-1811 (US).
LEISSLER-GERSTL, Gabriele; Eisenführ, Speiser & Partner Arnulfstr. 25 D-80335 München (DE)
Priority Data:
60/108,064 12.11.1998 US
Title (EN) METHODS AND COMPOSITIONS FOR TREATING COMMON COLD SYMPTOMS
(FR) METHODES ET COMPOSITIONS POUR LE TRAITEMENT DES SYMPTOMES DU RHUME
Abstract: front page image
(EN)The present invention provides methods of inhibiting replication of cold-causing viruses in respiratory epithelium cells and elaboration of IL-8 in the cells of subjects exposed to the viruses, by interfering with the virus binding to the cell membrane receptor that stimulates elaboration of IL-8 and viral replication. A polypeptide that binds to a virus and interferes with the binding of the virus to the cell is provided. An antibody that binds to a cell membrane-bound cytochrome and interferes with the virus binding to the cytochrome is also provided. Further, a chemical inhibitor of a membrane-bound cytochrome, that inhibitis viral replication in and elaboration of IL-8 by the cell, is provided. Moreover, the present invention provides methods of treating and reducing cold symptoms in a subject comprising administering to a subject any of the compositions of this invention. Further, the invention provides methods of screening for a compound which inhibits the interaction of a cold-causing virus and a respiratory epithelium cell.
(FR)L'invention concerne des méthodes permettant d'inhiber la réplication des virus provoquant le rhume dans des cellules épithéliales respiratoires et la production d'IL-8 dans les cellules d'un patient exposé auxdits virus, en empêchant la liaison du virus au récepteur membranaire cellulaire qui stimule la production d'IL-8 et la réplication virale; un polypeptide se liant à un virus et empêchant la fixation du virus sur la cellule; un anticorps se liant à un cytochrome membranaire et entravant la liaison du virus à ce cytochrome; un inhibiteur chimique d'un cytochrome membranaire, qui inhibe la réplication virale dans la cellule et la production d'IL-8 par celle-ci; des méthodes de traitement et d'atténuation des symptômes du rhume chez un sujet, qui consistent à administrer à ce dernier une des compositions de l'invention; et des méthodes de criblage permettant de rechercher un composé qui inhibe l'interaction d'un virus provoquant le rhume avec une cellule épithéliale respiratoire.
Designated States: AU, CA, JP, US.
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)