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Machine translation
1. (WO2000027374) THE USE OF EXCITATORY AMINO ACID TRANSPORTER INHIBITORS TO REDUCE CNS WHITE MATTER INJURY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/027374    International Application No.:    PCT/CA1999/001037
Publication Date: 18.05.2000 International Filing Date: 08.11.1999
Chapter 2 Demand Filed:    06.06.2000    
IPC:
A61K 31/00 (2006.01), A61K 31/198 (2006.01), A61K 31/40 (2006.01), A61K 31/401 (2006.01), A61K 31/403 (2006.01), A61K 31/551 (2006.01)
Applicants: LOEB HEALTH INSTITUTE AT THE OTTAWA HOSPITAL [CA/CA]; 725 Parkdale Avenue, Ottawa, Ontario K1Y 4E9 (CA) (For All Designated States Except US).
STYS, Peter [CA/CA]; (CA) (For US Only)
Inventors: STYS, Peter; (CA)
Agent: MBM & CO.; P.O. Box 809, Station B, Ottawa, Ontario K1P 5P9 (CA)
Priority Data:
2,252,996 06.11.1998 CA
2,282,236 16.09.1999 CA
Title (EN) THE USE OF EXCITATORY AMINO ACID TRANSPORTER INHIBITORS TO REDUCE CNS WHITE MATTER INJURY
(FR) UTILISATION D'INHIBITEURS DES TRANSPORTEURS D'ACIDES AMINES EXCITATEURS POUR REDUIRE LES LESIONS DE LA SUBSTANCE BLANCHE DU SYSTEME NERVEUX CENTRAL
Abstract: front page image
(EN)This invention provides a method of reducing the damaging effect of CNS white matter injury (including traumatic CNS injury, anoxia, and ischemia) to mammalian CNS tissue, particularly spinal cord tissue, by in vivo treatment thereof with inhibitors of excitatory amino acid transporters, such as the Na?+¿-dependent glutamate transporter and pharmaceutical compositions comprising said inhibitors.
(FR)L'invention se rapporte à une méthode permettant de réduire l'effet détériorant des liaisons de la substance blanche du système nerveux central (CNS) (notamment des traumatismes du CNS, l'anoxie et l'ischémie) sur le tissu du système nerveux central mammalien, notamment le tissu de la moelle épinière, et ce par traitement in vivo dudit tissu avec des inhibiteurs des transporteurs d'acides aminés excitateurs, tel que le transporteur de glutamate dépendant des ions sodium Na?+¿. L'invention se rapporte également à des compositions comportant de tels inhibiteurs.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)