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1. (WO2000027205) A RECOMBINANT POLYPEPTIDE FOR USE IN THE MANUFACTURE OF VACCINES AGAINST CAMPYLOBACTER INDUCED DIARRHEA AND TO REDUCE COLONIZATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/027205    International Application No.:    PCT/US1999/027195
Publication Date: 18.05.2000 International Filing Date: 12.11.1999
Chapter 2 Demand Filed:    12.11.1999    
IPC:
A61K 39/00 (2006.01), C07K 14/205 (2006.01), C07K 14/245 (2006.01)
Applicants: UNITED STATES GOVERNMENT as represented by THE SECRETARY OF THE NAVY [US/US]; 800 North Quincy Street Arlington, VA 22217-5660 (US) (For All Designated States Except US).
GUERRY, Patricia [US/US]; (US) (For US Only).
TRUST, Trevor [US/US]; (US) (For US Only).
BURG, Edward [US/US]; (US) (For US Only).
LEE, Lanfong [US/US]; (US) (For US Only)
Inventors: GUERRY, Patricia; (US).
TRUST, Trevor; (US).
BURG, Edward; (US).
LEE, Lanfong; (US)
Agent: HEMBY, Joseph, K., Jr.; Office of Intellectual Property Counsel Naval Medical Research Center 503 Grant Avenue Silver Spring, MD 20910 (US)
Priority Data:
60/108,114 12.11.1998 US
Title (EN) A RECOMBINANT POLYPEPTIDE FOR USE IN THE MANUFACTURE OF VACCINES AGAINST CAMPYLOBACTER INDUCED DIARRHEA AND TO REDUCE COLONIZATION
(FR) POLYPEPTIDE RECOMBINE DESTINE A ETRE UTILISE POUR LA FABRICATION DE VACCINS CONTRE LA DIARRHEE INDUITE PAR DES CAMPYLOBACTERIES, ET POUR LA REDUCTION DE LA COLONISATION
Abstract: front page image
(EN)This invention comprises a recombinant protein comprising the maltose binding protein (MBP) of $i(Escherichia coli) fused to amino acids 5-337 of the FlaA flagellin of $i(Campylobacter coli) VC167 which has provided evidence of immunogenicity and protective efficacy against challenge by a heterologous strain of $i(campylobacter, Campylobacter jejuni 81-176) in mammals. The invention further comprises a recombinant DNA construct encoding the immunodominant region (region I through III) of flagellin from Campylobacter spp. for use as a component of a vaccine against $i(Campylobacter diarrhea). The invention therefore represents an effective treatment against $i(Campylobacter) but avoids inducing the autoimmune Guillain Barre Syndrome (GBS), a post-infection polyneuropathy caused by $i(Campylobacter) molecular mimicry of human gangliosides which has hampered the development of vaccines heretofore.
(FR)L'invention concerne une protéine recombinée comprenant la protéine de liaison de la maltose (MBP) de $i(Escherichia coli) fusionnée aux acides aminés 5-337 de la flagelline FlaA de $i(Campylobacter coli) VC167, dont l'immunogénécité et la capacité de protection contre la provocation par un flux hétérologue de $i(campylobacter), $i(Campylobacter jejuni) $i(81-176), chez les mammifères, ont été prouvées. L'invention concerne également une construction d'ADN recombiné codant la région immunodominante (régions I à III) de flagelline de $i(Campylobacter) spp. destinée à être utilisée comme composant d'un vaccin contre la diarrhée à $i(Campylobacter). L'invention constitue en outre un traitement efficace contre les $i(Campylobacter), sans pour autant induire le syndrome auto-immun de Guillain-Barré (GBS), neuropathie multiple post-infectieuse provoquée par le mimétisme moléculaire de $i(Campylobacter) de gangliosides humains, qui entravait jusqu'ici le développement de vaccins appropriés.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)