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Machine translation
1. (WO2000026381) HIGH FIDELITY THERMOSTABLE LIGASE AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/026381    International Application No.:    PCT/US1999/025437
Publication Date: 11.05.2000 International Filing Date: 29.10.1999
Chapter 2 Demand Filed:    26.05.2000    
IPC:
C12N 9/00 (2006.01)
Applicants: CORNELL RESEARCH FOUNDATION, INC. [US/US]; Suite 105 20 Thornwood Drive Ithaca, NY 14850 (US) (For All Designated States Except US).
BARANY, Francis [US/US]; (US) (For US Only).
CAO, Weiguo [CN/US]; (US) (For US Only).
TONG, Jie [CN/US]; (US) (For US Only)
Inventors: BARANY, Francis; (US).
CAO, Weiguo; (US).
TONG, Jie; (US)
Agent: GOLDMAN, Michael, L.; Nixon Peabody LLP Clinton Square P.O. Box 1051 Rochester, NY 14603 (US)
Priority Data:
60/106,461 30.10.1998 US
Title (EN) HIGH FIDELITY THERMOSTABLE LIGASE AND USES THEREOF
(FR) LIGASE THERMOSTABLE HAUTE FIDELITE ET SES UTILISATIONS
Abstract: front page image
(EN)The present invention is directed to a thermostable ligase having substantially higher fidelity than either T4 ligase or $i(Thermus thermophilus) ligase. The DNA molecule encoding this enzyme as well as expression systems and host cells containing it are also disclosed. The thermostable ligase of the present invention is useful in carrying out a ligase detection reaction process and a ligase chain reaction process.
(FR)Cette invention concerne une ligase thermostable présentant une fidélité nettement supérieure à celle de la T4 ligase ou de la ligase $i(Thermus thermophilus). L'invention porte également sur la molécule d'ADN codant pour cet enzyme ainsi que pour les systèmes d'expression et les cellules hôtes qui la renferment. La ligase thermostable selon la présente invention convient pour la mise en oeuvre d'un processus de réaction de détection de ligase et d'un processus de réaction en chaîne de ligase.
Designated States: AU, CA, JP, US.
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)