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1. WO2000026227 - LDL RELATED PROTEIN AND USES THEREOF

Publication Number WO/2000/026227
Publication Date 11.05.2000
International Application No. PCT/US1999/025178
International Filing Date 27.10.1999
IPC
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
CPC
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 25/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
A61P 25/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
A61P 25/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
A61P 25/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
24Antidepressants
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants
  • MILLENNIUM PHARMACEUTICALS, INC. [US]/[US] (AllExceptUS)
Inventors
  • MCCARTHY, Sean, A.
Agents
  • MEIKLEJOHN, Anita, L.
Priority Data
09/183,17530.10.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) LDL RELATED PROTEIN AND USES THEREOF
(FR) PROTEINE APPARENTEE AUX LDL ET SON UTILISATION
Abstract
(EN)
The invention provides isolated nucleic acid molecules, designated TANGO 136 nucleic acid molecules, which encode transmembrane proteins with homology to members of the LDL receptor family of proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
(FR)
L'invention concerne des molécules d'acides nucléiques isolées, dénommées TANGO 136, qui codent pour des protéines transmembranaires présentant une homologie avec les protéines membres de la famille des récepteurs des LDL; des molécules d'acides nucléiques antisens, des vecteurs d'expression recombinants contenant les molécules d'acides nucléiques de l'invention, des cellules hôtes dans lesquelles ont été introduits lesdits vecteurs d'expression et des animaux transgéniques non humains chez lesquels une molécule d'acides nucléiques de l'invention a été introduite ou invalidée; des polypeptides isolés, des polypeptides de fusion, des peptides antigéniques et des anticorps; et des méthodes de diagnostic, de criblage et de traitement faisant appel aux compositions de l'invention.
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