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Pub. No.:    WO/2000/026210    International Application No.:    PCT/US1999/025041
Publication Date: 11.05.2000 International Filing Date: 26.10.1999
Chapter 2 Demand Filed:    11.05.2000    
C07D 401/14 (2006.01), C07D 403/12 (2006.01), C07D 405/14 (2006.01), C07D 413/12 (2006.01), C07D 471/04 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue, Rahway, NJ 07065-0907 (US) (For All Designated States Except US).
SANDERSON, Philip, E. [GB/US]; (US) (For US Only).
LYLE, Terry [US/US]; (US) (For US Only).
DORSEY, Bruce [US/US]; (US) (For US Only).
STANTON, Matthew, G. [US/US]; (US) (For US Only).
NAYLOR-OLSEN, Adel, M. [US/US]; (US) (For US Only)
Inventors: SANDERSON, Philip, E.; (US).
LYLE, Terry; (US).
DORSEY, Bruce; (US).
STANTON, Matthew, G.; (US).
MERCK & CO., INC.; 126 East Lincoln Avenue, Rahway, NJ 07065-0907 (US)
Priority Data:
60/106,294 30.10.1998 US
Abstract: front page image
(EN)Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having structure (I) or a pharmaceutically acceptable salt thereof, wherein b is NY?1¿ or O; c is CY?2¿ or N; d is CY?2¿; e is CY?1¿ or N; f is CY?1¿ or N; g is CY?1¿ or N; Y?1¿ is hydrogen, C¿1-4? alkyl, or halogen; Y?2¿ is hydrogen, C¿1-4? alkyl, C¿3-7? cycloalkyl, halogen, NH¿2?, OH or C¿1-4? alkoxy; A is (II), (III), (IV) or (V); and W, X, Z, R?3¿, R?4¿ and R?5¿ are defined in the specification.
(FR)L'invention concerne des composés destinés à être utilisés pour inhiber la thrombine et les occlusions thrombotiques associées à celle-ci, ces composés présentant la structure (I), ou un sel pharmaceutiquement acceptable de celle-ci. Dans cette structure, b représente NY?1¿ ou O; c désigne CY?2¿ ou N; d symbolise CY?2¿; e représente CY?1¿ ou N; f représente CY?1¿ ou N; g désigne CY?1¿ ou N; Y?1¿ symbolise hydrogène, alkyle C¿1-4?, ou halogène; et Y?2¿ représente hydrogène, alkyle C¿1-4?, cycloalkyle C¿3-7?, halogène, NH¿2?, OH, ou alkoxy C¿1-4? ; A symbolise (II), (III), (IV), ou (V); et W, X, Z, R?3¿, R?4¿, et R?5¿ sont tels que définis dans le mémoire descriptif.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)