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1. (WO2000026209) ANTI-INFLAMMATORY 4-PHENYL-5-PYRIMIDINYL-IMIDAZOLES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/026209    International Application No.:    PCT/EP1999/008358
Publication Date: 11.05.2000 International Filing Date: 02.11.1999
Chapter 2 Demand Filed:    08.05.2000    
IPC:
C07D 401/14 (2006.01), C07D 403/04 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Schwarzwaldallee 215, CH-4058 Basel (CH) (AE, AL, AM, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CR, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW only).
NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. [AT/AT]; Brunner Strasse 59, A-1230 Vienna (AT) (AT only).
REVESZ, Laszlo [CH/CH]; (CH) (For US Only)
Inventors: REVESZ, Laszlo; (CH)
Agent: BECKER, Konrad; Novartis AG, Corporate Intellectual Property, Patent & Trademark Department, CH-4002 Basel (CH)
Priority Data:
9824063.3 03.11.1998 GB
9903440.7 15.02.1999 GB
Title (EN) ANTI-INFLAMMATORY 4-PHENYL-5-PYRIMIDINYL-IMIDAZOLES
(FR) 4-PHENYL-5-PYRIMIDINYL-IMIDAZOLES ANTI-INFLAMMATOIRES
Abstract: front page image
(EN)Novel 4- phenyl- 5-(2- aryl-X)- 4-pyrimidinyl-, 4- phenyl-5- (2-cycloalkyl- X)-4-pyrimidinyl-, 4- phenyl-5- (-aralkyl-X)-4- pyrimidinyl- or 4-phenyl- 5-(2-cycloalkylalkyl- X)-4-pyrimidinyl- imidazoles, in which the 5- pyrimidinyl substituent is aryl, cycloalkyl, aralkyl or cycloalkylalkyl substituted directly via a heteroatom X selected from N, O or S, and pharmaceutically-acceptable and -cleavable esters thereof and acid addition salts thereof are provided, in particular compounds of formula (I), wherein the symbols are as defined, which are MAP kinase inhibitors, useful pharmaceutically for treating TNF$g(a) and IL-1 mediated diseases such as rheumatoid arthritis and diseases of bone metabolism, e.g. osteoporosis.
(FR)Nouveaux 4-phényl-5-(2-aryl-X)-4-pyrimidinyl-, 4-phényl-5-(2-cycloalkyle-X)-4-pyrimidinyle-, 4-phényl-5-(-aralkyle-X)-4-pyrimidinyl- ou 4-phényl-5-(2-cycloalkylalkyl-X)-4-pyrimidinyle imidazoles dans lesquels le substituant 5-pyrimidinyle est aryle, cycloalkyle, aralkyle ou cycloalkylalkyle substitué directement par l'intermédiaire d'un hétéroatome X sélectionné dans N, O ou S, ainsi que leurs sels acceptables sur le plan pharmaceutique et pouvant être clivés et leurs sels d'apport acide, en particulier des composés représentés par la formule (I), dans laquelle les symboles sont comme définis, à savoir des inhibiteurs de MAP kinases, utiles pharmaceutiquement pour traiter TNF$g(a) et des maladies dans lesquelles IL-1 joue un rôle d'intermédiaire, telles que la polyarthrite rhumatoïde et les maladies du métabolisme osseux, par exemple, l'ostéoporose.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)