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Machine translation
1. (WO2000026199) USE OF N-SUBSTITUTED (3,6-DIHYDRO)-2H-1,2-OXAZINE DERIVATIVES AS SELECTIVE MGLUR1 ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/026199    International Application No.:    PCT/GB1999/003607
Publication Date: 11.05.2000 International Filing Date: 01.11.1999
Chapter 2 Demand Filed:    17.05.2000    
IPC:
C07D 265/02 (2006.01)
Applicants: ELI LILLY AND COMPANY LIMITED [GB/GB]; Kingsclere Road Basingstoke Hampshire RG21 6XA (GB) (For All Designated States Except US).
CLARK, Barry, Peter [GB/GB]; (GB) (For US Only).
HARRIS, John, Richard [GB/GB]; (GB) (For US Only).
KINGSTON, Ann, Elizabeth [GB/US]; (US) (For US Only)
Inventors: CLARK, Barry, Peter; (GB).
HARRIS, John, Richard; (GB).
KINGSTON, Ann, Elizabeth; (US)
Agent: DENHOLM, Anna, Marie; Eli Lilly and Company Limited Lilly Research Centre Erl Wood Manor Windlesham Surrey GU20 6PH (GB)
Priority Data:
9823845.4 02.11.1998 GB
Title (EN) USE OF N-SUBSTITUTED (3,6-DIHYDRO)-2H-1,2-OXAZINE DERIVATIVES AS SELECTIVE MGLUR1 ANTAGONISTS
(FR) COMPOSES PHARMACEUTIQUES
Abstract: front page image
(EN)Use of a compound of formula (I) in which, R?1¿, R?2¿ and R?3¿ are independently hydrogen, (C¿1?-C¿6?)alkyl, (C¿2?-C¿6?)alkenyl, (C¿3?-C¿10?)cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted aryl(C¿1?-C¿6?)alkyl, unsubstituted or substituted aryl(c¿2?-C¿6?)alkenyl, halo, carboxy, (C¿1?-C¿6?)alkoxycarbonyl or -(CH¿2?)¿m?-OH wherein m is 1, 2 or 3; --- indicates a single or a double bond; X and Y are each independently hydrogen, or X and Y together represent a bridge of the formula -(CH¿2?)¿n?-, where n is 1 or 2; A¿1? and A¿2? are each independently an unsubstituted or substituted aryl; Z is -CO-, -SO¿2?- or -CH¿2?-; provided that, when Z is -CO-, A¿1? is not 3,4,5-trimethoxyphenyl; or a pharmaceutically-acceptable salt or ester thereof, for the manufacture of a medicament for the treatment of a condition indicating the administration of a selective mGluR1 antagonist.
(FR)L'invention concerne l'utilisation d'un composé de formule (I) répondant à la définition du descriptif, ou d'un sel ou d'un ester pharmaceutiquement acceptables de ce composé, pour la préparation d'un médicament destiné au traitement d'un trouble pour lequel l'administration d'un antagoniste sélectif de mGluR1 est indiquée.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)