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Machine translation
1. (WO2000026193) METHOD FOR PRODUCING 4- [(2',5'- DIAMINO-6'- HALOPYRIMIDINE- 4'-YL)AMINO]- CYCLOPENT- 2-ENYLMETHANOLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/026193    International Application No.:    PCT/EP1999/008270
Publication Date: 11.05.2000 International Filing Date: 29.10.1999
Chapter 2 Demand Filed:    16.03.2000    
IPC:
C07D 239/50 (2006.01)
Applicants: LONZA AG [CH/CH]; Münchensteinerstrasse 38 CH-4052 Basel (CH) (For All Designated States Except US).
BRIEDEN, Walter [DE/CH]; (CH) (For US Only).
SAIKALI, Elie [US/CH]; (CH) (For US Only)
Inventors: BRIEDEN, Walter; (CH).
SAIKALI, Elie; (CH)
Agent: RITTHALER, Wolfgang; Winter, Brandl et al. Alois-Steinecker-Strasse 22 D-85435 Freising (DE)
Priority Data:
98120529.7 30.10.1998 EP
60/146,105 29.07.1999 US
Title (DE) VERFAHREN ZUR HERSTELLUNG VON 4-[(2',5'-DIAMINO-6'-HALOGENPYRIMIDIN-4'-YL)AMINO]-CYCLOPENT-2-ENYLMETHANOLEN
(EN) METHOD FOR PRODUCING 4- [(2',5'- DIAMINO-6'- HALOPYRIMIDINE- 4'-YL)AMINO]- CYCLOPENT- 2-ENYLMETHANOLS
(FR) PROCEDE DE PRODUCTION DE 4- [(2',5'- DIAMINO-6'- HALOPYRIMIDIN- 4'-YL)AMINO]- CYCLOPENT-2- ENYLMETHANOLS
Abstract: front page image
(DE)Beschrieben wird ein neues Verfahren zur Herstellung von 4- [(2',5'-Diamino- 6'-halogenpyrimidin- 4'-yl)amino]cyclopent- 2-enylmethanolen der allgemeinen Formel (I), worin X ein Halogenatom bedeutet. Bei diesem Verfahren wird ein 2,5- Diamino-4,6- dihalogenpyrimidin der allgemeinen Formel (II), worin X die genannte Bedeutung hat, mit einem 4- Aminocyclopent- 2-enylmethanol der Formel (III) oder einem Salz davon in Gegenwart einer Base in einem polar protischen Lösungsmittel umgesetzt.
(EN)The invention relates to a novel method for producing 4- [(2',5'-diamino- 6'-halopyrimidine- 4'-yl)amino]- cyclopent- 2-enylmethanols of general formula (I), wherein X represents a halogen atom. According to the inventive method, a 2,5-diamino-4,6-halopyrimidine of general formula (II), wherein X has the aforementioned meaning, is reacted with a 4- aminocyclopent-2- enylmethanol of formula (III) or with a salt thereof in the presence of a base in a polar protic solvent.
(FR)L'invention concerne un nouveau procédé de 4-[(2',5'-diamino-6'-halopyrimidin-4'-yl)amino]cyclopent-2-énylméthanols de formule générale (I) dans laquelle X représente un atome d'halogène. Selon ce procédé, une 2,5-diamino-4,6-dihalopyrimidine de formule générale (II), dans laquelle X a la signification mentionnée, réagit avec un 4-aminocyclopent-2-énylméthanol de formule (III) ou avec un sel de ce dernier en présence d'une base dans un solvant polaire protique.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: German (DE)
Filing Language: German (DE)