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1. WO2000025831 - A NEW COMPOSITION AND METHOD FOR INCREASING PRODUCTION YIELD OF AGRICULTURALLY USEFUL SPECIES

Publication Number WO/2000/025831
Publication Date 11.05.2000
International Application No. PCT/IL1999/000585
International Filing Date 03.11.1999
Chapter 2 Demand Filed 02.06.2000
IPC
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 47/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C07K 19/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
CPC
A61K 2039/6081
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
60characteristics by the carrier linked to the antigen
6031Proteins
6081Albumin; Keyhole limpet haemocyanin [KLH]
A61K 39/0005
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
0005Vertebrate antigens
A61K 47/643
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
643Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
C07K 19/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
Applicants
  • FEDERMAN & SONS (HOLDINGS) LTD. [IL]/[IL] (AllExceptUS)
  • ZIV, Nitzan [IL]/[IL] (UsOnly)
  • SCHWARTZBORD, Boris [IL]/[IL] (UsOnly)
  • LUXEMBOURG, Danny [IL]/[IL] (UsOnly)
Inventors
  • ZIV, Nitzan
  • SCHWARTZBORD, Boris
  • LUXEMBOURG, Danny
Agents
  • BRASS, Daniel
Priority Data
12687403.11.1998IL
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A NEW COMPOSITION AND METHOD FOR INCREASING PRODUCTION YIELD OF AGRICULTURALLY USEFUL SPECIES
(FR) COMPOSITIONS ET PROCEDES AMELIORES SERVANT A AUGMENTER LA PRODUCTIVITE D'ESPECES AGRICOLES UTILES
Abstract
(EN)
An economically effective method and composition thereof, for enhancing the production yield of agriculturally useful animals, in particular mammals such as sheep and poultry such as chickens, through the administration of a novel composition for fertility enhancement which contains substantially low concentrations of an immunogen, which is a conjugated inhibin or a fragment thereof. These concentrations are preferably in the range of from about 5 to about 500 micrograms immunogen per ml of composition, and more preferably in the range of from about 20 to about 300 micrograms immunogen per ml of composition. The fertility-enhancing is useful for mammals, in particular sheep, and for poultry animals, in particular chickens, and is effective under commercial farm conditions. The composition features inhibin or a fragment thereof, linked to a carrier protein emulsified with an adjuvant. Preferably, the immunogen includes the N-terminal sequence (amino acids 1-29) of the alpha sub-unit of bovine inhibin conjugated to keyhole limpet hemocyanin (KLH) at a ratio of 1:40 peptide/KLH.
(FR)
Procédé et composition efficaces sur le plan économique servant à augmenter la productivité d'animaux utiles sur le plan agricole, en particulier des mammifères, tels que des moutons, et de la volaille, tels que des poulets, au moyen de l'administration d'une nouvelle composition servant à améliorer la fertilité et contenant des concentrations sensiblement basses d'un immunogène, qui est une inhibine conjuguée ou un de ses fragments. Ces concentrations sont, de préférence, dans une plage de 5 à 500 microgrammes d'immunogène par ml de composition et, encore de préférence, dans une plage de 20 à 300 microgrammes d'immunogène par ml de composition. Cette composition est utile pour des mammifères, en particulier des moutons, ainsi que pour des volailles, en particulier, des poulets et est efficace dans des conditions d'élevage commercial. Cette composition contient inhibine ou un de ses fragments, relié à une protéine de support émulsionnée avec un adjuvant. De préférence, l'immunogène comprend la séquence à terminaison N (acides aminés 1-29) de la sous-unité alpha de l'inhibine bovine conjuguée à hémocyanine de fissurelle (KLH) à un rapport de 1 :40 peptide/KLH.
Also published as
ESP200150032
ZA200103124
Latest bibliographic data on file with the International Bureau