WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2000025776) NITROSATED AND NITROSYLATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/025776    International Application No.:    PCT/US1999/025481
Publication Date: 11.05.2000 International Filing Date: 29.10.1999
Chapter 2 Demand Filed:    05.05.2000    
IPC:
A61K 45/06 (2006.01), C07C 381/00 (2006.01), C07D 207/08 (2006.01), C07D 209/28 (2006.01), C07D 211/22 (2006.01), C07D 211/26 (2006.01), C07D 211/54 (2006.01), C07D 211/62 (2006.01), C07D 239/46 (2006.01), C07D 241/06 (2006.01), C07D 263/20 (2006.01), C07D 295/088 (2006.01), C07D 295/185 (2006.01), C07D 295/192 (2006.01), C07D 317/32 (2006.01), C07F 9/40 (2006.01)
Applicants: NITROMED, INC. [US/US]; 12 Oak Park Drive Bedford, MA 01730 (US) (For All Designated States Except US).
BANDARAGE, Upul, K. [LK/US]; (US) (For US Only).
DONG, Qing [CN/US]; (US) (For US Only).
FANG, Xinqin [CN/US]; (US) (For US Only).
GARVEY, David, S. [US/US]; (US) (For US Only).
MERCER, Gregory, J. [US/US]; (US) (For US Only).
RICHARDSON, Stewart, K. [GB/US]; (US) (For US Only).
SCHROEDER, Joseph, D. [US/US]; (US) (For US Only).
WANG, Tiansheng [CN/US]; (US) (For US Only)
Inventors: BANDARAGE, Upul, K.; (US).
DONG, Qing; (US).
FANG, Xinqin; (US).
GARVEY, David, S.; (US).
MERCER, Gregory, J.; (US).
RICHARDSON, Stewart, K.; (US).
SCHROEDER, Joseph, D.; (US).
WANG, Tiansheng; (US)
Agent: GRIEFF, Edward, D.; Hale and Dorr LLP 1455 Pennsylvania Avenue, N.W. Washington, DC 20004 (US)
Priority Data:
09/182,433 30.10.1998 US
Title (EN) NITROSATED AND NITROSYLATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE
(FR) COMPOSES ANTI-INFLAMMATOIRES NON STEROIDIENS NITROSES ET NITROSYLES, COMPOSITIONS ET PROCEDES D'UTILISATION
Abstract: front page image
(EN)The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs; treating and/or preventing gastrointestinal disorders; treating inflammatory disease states and disorders; and treating and/or preventing ophthalmic diseases or disorders.
(FR)L'invention concerne de nouveaux composés anti-inflammatoires non stéroïdiens nitrosés et/ou nitrosylés, et de nouvelles compositions comprenant au moins un composé anti-inflammatoire non stéroïdien nitrosé et/ou nitrosylé et, éventuellement, au moins un composé fournissant, transférant ou libérant de l'oxyde nitrique, élevant des niveaux endogènes du facteur relaxant dérivé de l'endothélium, simulant la synthèse endogène de l'oxyde nitrique, ou qui est un substrat de synthase d'oxyde nitrique. L'invention concerne également des procédés pour le traitement, la prévention et/ou la diminution de l'inflammation, de la douleur et de la fièvre, l'abaissement ou la réversion de la toxicité gastro-intestinale, rénale et autres toxicités résultant de l'utilisation de médicaments anti-inflammatoires non stéroïdiens, le traitement et/ou la prévention de troubles gastro-intestinaux, le traitement d'états d'affection et de troubles inflammatoires, ainsi que le traitement et/ou la prévention d'affections ou de troubles ophtalmiques.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)