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1. WO2000024940 - CELLULAR ARRAYS AND METHODS OF DETECTING AND USING GENETIC DISORDER MARKERS

Publication Number WO/2000/024940
Publication Date 04.05.2000
International Application No. PCT/US1999/025370
International Filing Date 28.10.1999
Chapter 2 Demand Filed 26.05.2000
IPC
B01L 3/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
G01N 1/08 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
1Sampling; Preparing specimens for investigation
02Devices for withdrawing samples
04in the solid state, e.g. by cutting
08involving an extracting tool, e.g. core bit
G01N 1/31 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
1Sampling; Preparing specimens for investigation
28Preparing specimens for investigation
30Staining; Impregnating
31Apparatus therefor
G02B 21/34 2006.01
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
34Microscope slides, e.g. mounting specimens on microscope slides
CPC
B01J 2219/00659
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00583Features relative to the processes being carried out
00603Making arrays on substantially continuous surfaces
00659Two-dimensional arrays
B01J 2219/00702
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
0068Means for controlling the apparatus of the process
00702Processes involving means for analysing and characterising the products
B01J 2219/00743
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00718Type of compounds synthesised
0072Organic compounds
0074Biological products
00743Cells
B01L 3/5085
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware
50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
508rigid containers not provided for above
5085for multiple samples, e.g. microtitration plates
C12Q 1/6809
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6809Methods for determination or identification of nucleic acids involving differential detection
C12Q 1/6837
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6813Hybridisation assays
6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
6837using probe arrays or probe chips
Applicants
  • VYSIS, INC. [US]/[US]
  • THE UNITED STATES OF AMERICA as represented by THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES [US]/[US]
Inventors
  • KALLIONIEMI, Olli-P.
  • MÜLLER, Uwe, Richard
  • SAUTER, Giudo
  • KONONEN, Juha
  • BARLUND, Maarit
Agents
  • FASSE, J., Peter
Priority Data
60/106,03828.10.1998US
60/150,49324.08.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CELLULAR ARRAYS AND METHODS OF DETECTING AND USING GENETIC DISORDER MARKERS
(FR) RESEAUX CELLULAIRES ET METHODES DE DETECTION ET D'UTILISATION DE MARQUEURS DE TROUBLES GENETIQUES
Abstract
(EN)
A method is disclosed for rapid molecular profiling of tissue or other cellular specimens by placing a donor specimen in an assigned location in a recipient array, providing copies of the array, and performing a different biological analysis of each copy. The results of the different biological analyses are compared to determine if there are correlations between the results of the different biological analyses at each assigned location. In some embodiment, the specimens may be tissue specimens from different tumors, which are subjected to multiple parallel molecular (including genetic and immunological) analyses. The results of the parallel analyses are then used to detect common molecular characteristics of the genetic disorder type, which can subsequently be used in the diagnosis or treatment of the disease. The biological characteristics of the tissue can be correlated with clinical or other information, to detect characteristics associated with the tissue, such as susceptibility or resistance to particular types of drug treatment. Other examples of suitable tissues which can be placed in the matrix include tissue from transgenic or model organisms, or cellular suspensions (such as cytological preparations or specimens of liquid malignancies or cell lines).
(FR)
L'invention concerne une méthode déterminant rapidement le profil moléculaire d'échantillons de tissus et autres échantillons cellulaires consistant à mettre en place un échantillon de donneur dans un emplacement attribué dans un réseau de récipients, à fournir des copies du réseau, et à procéder à une analyse biologique différente de chaque copie. Les résultats des différentes analyses biologiques sont comparés pour déterminer s'il existe des corrélations entre les résultats des différentes analyses biologiques à chaque emplacement attribué. Dans certains modes de réalisation, les échantillons peuvent être des échantillons de tissus provenant de différentes tumeurs, lesquels sont soumis à des analyses moléculaires multiples parallèles (notamment génétiques et immunologiques). Les résultats des analyses parallèles sont alors utilisés pour détecter des caractéristiques moléculaires communes du type de trouble génétique, lesquelles peuvent être ensuite utilisées dans le diagnostic ou le traitement de la maladie. Les caractéristiques biologiques des tissus peuvent être corrélées aux informations cliniques ou autres, afin de détecter des caractéristiques associées aux tissus, telles que la sensibilité ou la résistance à des types particuliers de traitements médicamenteux. D'autres exemples de tissus appropriés pouvant être placés dans la matrice comprennent des tissus provenant d'organismes transgéniques ou de cobayes, ou des suspensions cellulaires (telles que des préparations ou des échantillons cytologiques de malignités liquides ou de lignées cellulaires).
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