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1. (WO2000024870) NUCLEIC ACIDS AND PROTEINS OF THE HUMAN SPAN-X GENE AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/024870    International Application No.:    PCT/US1999/024973
Publication Date: 04.05.2000 International Filing Date: 22.10.1999
Chapter 2 Demand Filed:    17.05.2000    
IPC:
C07K 14/47 (2006.01)
Applicants: UNIVERSITY OF VIRGINIA PATENT FOUNDATION [US/US]; Suite 1-110 Towers Office Building 1224 West Main Street Charlottesville, VA 22903 (US) (For All Designated States Except US).
HERR, John, C. [US/US]; (US) (For US Only).
WESTBROOK, V., Anne [US/US]; (US) (For US Only).
DIEKMAN, Alan, B. [US/US]; (US) (For US Only)
Inventors: HERR, John, C.; (US).
WESTBROOK, V., Anne; (US).
DIEKMAN, Alan, B.; (US)
Agent: BALDWIN, Geraldine, F.; Pennie & Edmonds LLP 1155 Avenue of the Americas New York, NY 10036 (US)
Priority Data:
60/105,324 23.10.1998 US
Title (EN) NUCLEIC ACIDS AND PROTEINS OF THE HUMAN SPAN-X GENE AND USES THEREOF
(FR) ACIDES NUCLEIQUES ET PROTEINES DU GENE HUMAIN SPAN-X ET LEUR UTILISATION
Abstract: front page image
(EN)The present invention provides the discovery, identification and characterization of nucleotides that encode a novel X-linked spermatozoan nuclear protein, SPAN-X. The invention encompasses nucleotides encoding SPAN-X, proteins encoded by the nucleotides of the present invention, and antibodies and ligands that bind SPAN-X as well as fragments of any of the above having a functional activity of SPAN-X, $i(e.g.), a nuclear localization signal activity, etc. The present invention provides screening assays to identify SPAN-X-bearing spermatids. The invention further provides compositions and methods for the use of $i(span-x) nucleic acids for heterologous gene expression.
(FR)La présente invention se rapporte à la découverte, à l'identification et à la caractérisation de nucléotides codant SPAN-X, nouvelle protéine nucléaire de spermatozoïde liée à X. L'invention englobe les nucléotides codant SPAN-X, les protéines codées par les nucléotides de la présente invention et les anticorps et ligands qui lient SPAN-X ainsi que les fragments de tous les éléments précités qui ont une activité fonctionnelle de SPAN-X telle que l'activité de signal de localisation nucléaire ou autre. La présente invention propose des dosages de criblage permettant d'identifier les spermatides porteurs de SPAN-X. L'invention concerne en outre des compositions et des procédés destinés à l'utilisation des acides nucléiques de SPAN-X pour l'expression de gènes hétérologues.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)