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1. (WO2000024773) INHIBITION OF TRANSGLUTAMINASE-MEDIATED MICROBIAL INFECTION OF A MAMMALIAN HOST
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/024773    International Application No.:    PCT/US1999/025043
Publication Date: 04.05.2000 International Filing Date: 26.10.1999
Chapter 2 Demand Filed:    25.05.2000    
IPC:
A61K 39/00 (2006.01), C07K 14/40 (2006.01)
Applicants: SUNDSTROM, Paula [US/US]; (US)
Inventors: SUNDSTROM, Paula; (US).
BRADWAY, Steven; (US)
Agent: PELTO, Don; McKenna & Cuneo, LLP 1900 K Street, NW Washington, DC 20006 (US)
Priority Data:
09/178,509 26.10.1998 US
Title (EN) INHIBITION OF TRANSGLUTAMINASE-MEDIATED MICROBIAL INFECTION OF A MAMMALIAN HOST
(FR) INHIBITION DE L'INTERACTION MICROBIENNE INDUITE PAR LA TRANSGLUTAMINASE AVEC UN MAMMIFERE HOTE
Abstract: front page image
(EN)The infection of a mammalian host by a microorganism Candida albicans can be prevented or treated through the administration the substrate for transglutaminases Hwp or antibodies against this substrates that inhibit the transglutaminase-mediated interaction of the microorganism with the mammalian host. These compounds may be used in the identification, prevention or treatment of microbial infection of mammalian hosts such as immunocompromised or immunosuppressed humans, for example, those having AIDS or undergoing transplantation or anti-cancer therapy.
(FR)Il est possible d'empêcher ou de traiter l'infection d'un mammifère hôte par un micro-organisme, par administration de substrats pour transglutaminases ou d'anticorps contre ces substrats inhibant l'interaction induite par la transglutaminase dudit micro-organisme avec un mammifère hôte. Ces composés peuvent être utilisés pour identifier, prévenir ou traiter une infection microbienne chez des mammifères hôtes, tels que des humains présentant un déficit immunitaire ou immunosuppressifs, par exemple, ceux atteint du SIDA ou ceux ayant subi une transplantation ou une thérapie anti-cancer.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)