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Machine translation
1. (WO2000024768) GENES INTEGRATING SIGNAL TRANSDUCTION PATHWAYS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/024768    International Application No.:    PCT/US1999/024826
Publication Date: 04.05.2000 International Filing Date: 22.10.1999
Chapter 2 Demand Filed:    22.05.2000    
IPC:
A61K 38/00 (2006.01), C07K 14/82 (2006.01)
Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; 77 Massachusetts Avenue Cambridge, MA 02138 (US) (For All Designated States Except US).
KAWASAKI, Hiroaki [JP/JP]; (JP) (For US Only).
GRAYBIEL, Ann [US/US]; (US) (For US Only).
HOUSMAN, David [US/US]; (US) (For US Only)
Inventors: KAWASAKI, Hiroaki; (JP).
GRAYBIEL, Ann; (US).
HOUSMAN, David; (US)
Agent: CAMACHO, Jennifer, A.; Testa, Hurwitz & Thibeault, LLP High Street Tower 125 High Street Boston, MA 02110 (US)
Priority Data:
60/105,507 23.10.1998 US
60/108,685 16.11.1998 US
Title (EN) GENES INTEGRATING SIGNAL TRANSDUCTION PATHWAYS
(FR) GENES INTEGRANT DES TRAJETS DE TRANSDUCTION DE SIGNAUX
Abstract: front page image
(EN)The present invention describes the identification, isolation, sequencing and characterization of two human CalDAG-GEF, and two human cAMP-GEF genes, which are associated with the Ras pathway. Also identified are CalDAG-GEF gene homologues in mice and cAMP-GEF gene homologues in rats. Nucleic acids and proteins comprising or derived from the CalDAG-GEFs and/or cAMP-GEFs are useful in screening and diagnosing certain Ras-associated cancers, in identifying and developing therapeutics for treatment of certain Ras-associated cancers, and in producing cell lines and transgenic animals useful as models of Ras-associated cancers.
(FR)L'invention concerne l'identification, l'isolement, le séquençage et la caractérisation de deux gènes humains CalDAG-GEF et cAMP-GEF, qui sont associés au trajet Ras. Les homologues génétiques CalDAG-GEF chez la souris sont également identifiés. Les acides nucléiques et les protéines comprenant ou dérivées des gènes CalDAG-GEF and/ou cAMP-GE sont employées pour le criblage et le diagnostic de certains cancers associés à la Ras, l'identification et la mise au point de méthodes thérapeutiques destinées au traitement de certains cancers associés à la Ras, et la production de lignées cellulaires et d'animaux transgéniques servant de modèles de cancers associés à la Ras.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)