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Machine translation
1. (WO2000024753) CHROMOGENIC SUBSTRATES OF SIALIDASE AND METHODS OF MAKING AND USING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/024753    International Application No.:    PCT/US1998/022786
Publication Date: 04.05.2000 International Filing Date: 27.10.1998
Chapter 2 Demand Filed:    21.05.1999    
IPC:
C12Q 1/04 (2006.01), C12Q 1/34 (2006.01)
Applicants: IBBEX, INC. [US/US]; Suite 373 2800 Milan Court Birmingham, AL 35211 (US).
UAB RESEARCH FOUNDATION [US/US]; 1120-G Administration Building 701 20th Street South Birmingham, AL 35294 (US)
Inventors: JOHNSON, Stephen, C.; (US).
SAEED, Ashraf; (US).
LUO, Ming; (US)
Agent: SALIWANCHIK, David, R.; Saliwanchik, Lloyd & Saliwanchik Suite A-1 2421 NW 41st Street Gainesville, FL 32606-6669 (US)
Priority Data:
08/958,356 27.10.1998 US
Title (EN) CHROMOGENIC SUBSTRATES OF SIALIDASE AND METHODS OF MAKING AND USING THE SAME
(FR) SUBSTRATS CHROMOGENES DE SIALIDASE ET LEURS PROCEDES DE PREPARATION ET D'UTILISATION
Abstract: front page image
(EN)The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidases take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.
(FR)L'invention concerne des matériaux et des procédés permettant la conception, la synthèse et l'évaluation biochimique de composés de substrat chromogène dans le cadre des sialidases d'origine bactérienne, virale, protozoaire et vertébrée (y compris les êtres humains). L'invention concerne plus particulièrement une nouvelle classe de composés efficaces en tant que substrats chromogènes de ces sialidases qui génèrent des produits chromogènes après qu'ont eu lieu des réactions catalysées par sialidase. Font aussi l'objet de cette invention des procédés de préparation de ces composés de substrat, des techniques de diagnostic et pronostic des maladies associées à la sialidase utilisant ces composés de substrat.
Designated States: AU, CA, JP.
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)