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1. (WO2000024734) LIPOIC ACID DERIVATIVES AND THEIR USE IN TREATMENT OF DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/024734    International Application No.:    PCT/US1999/025140
Publication Date: 04.05.2000 International Filing Date: 26.10.1999
Chapter 2 Demand Filed:    02.05.2000    
IPC:
C07C 311/49 (2006.01), C07C 323/52 (2006.01), C07D 339/04 (2006.01), C07F 19/00 (2006.01)
Applicants: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK [US/US]; P.O. Box 9 Albany, NY 12201 (US)
Inventors: BINGHAM, Paul, M.; (US).
ZACHAR, Zuzana; (US)
Agent: RICHTER, Kurt, E.; Morgan & Finnegan, LLP 345 Park Avenue New York, NY 10154 (US)
Priority Data:
60/105,628 26.10.1998 US
Title (EN) LIPOIC ACID DERIVATIVES AND THEIR USE IN TREATMENT OF DISEASE
(FR) DERIVES D'ACIDE LIPOIQUE ET UTILISATION DE CES DERIVES POUR LE TRAITEMENT DE MALADIES
Abstract: front page image
(EN)This invention relates to the identification of a novel class of therapeutic agents which selectively target and kill tumor cells and certain other types of diseased cells, and to compositions comprising lipoic acid derivatives which poison the pyruvate dehydrogenase complex specifically in such cells. This invention also provides for methods of using therapeutically effective amounts of the lipoic acid derivatives for the treatment of cancer and other diseases. The lipoic acid derivatives described herein have a wide range of preventive and therapeutic applications.
(FR)L'invention concerne l'identification d'une nouvelle classe d'agents thérapeutiques qui ciblent et détruisent de manière sélective les cellules tumorales et certains autres types de cellules malades, ainsi que des compositions comprenant des dérivés d'acide lipoïque attaquant spécifiquement le complexe pyruvate déshydrogénase dans ces cellules. L'invention concerne également des traitements contre le cancer et d'autres maladies, comprenant l'administration de quantités thérapeutiquement efficaces de dérivés d'acide lipoïque. Ces dérivés d'acide lipoïque présentent un large éventail d'applications thérapeutiques.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)