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Machine translation
1. (WO2000024717) ISOQUINOLINE DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/024717    International Application No.:    PCT/EP1999/007761
Publication Date: 04.05.2000 International Filing Date: 06.10.1999
Chapter 2 Demand Filed:    03.05.2000    
IPC:
C07D 217/14 (2006.01), C07D 401/12 (2006.01), C07D 471/04 (2006.01)
Applicants: SMITHKLINE BEECHAM P.L.C. [GB/GB]; New Horizons Court Brentford Middlesex TW8 9EP (GB) (For All Designated States Except US).
JOHNSON, Christopher, Norbert [GB/GB]; (GB) (For US Only).
STEMP, Geoffrey [GB/GB]; (GB) (For US Only)
Inventors: JOHNSON, Christopher, Norbert; (GB).
STEMP, Geoffrey; (GB)
Agent: GARRETT, Michael; SmithKline Beecham Corporate Intellectual Property Two New Horizons Court Brentford, Middlesex TW8 9EP (GB)
Priority Data:
9821977.7 08.10.1998 GB
Title (EN) ISOQUINOLINE DERIVATIVES
(FR) COMPOSES
Abstract: front page image
(EN)Compounds of formula (I) wherein: R?1¿ represents a substituent selected from: a hydrogen or halogen atom; a hydroxy, cyano, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethanesulfonyloxy, pentafluoroethyl, C¿1-4?alkyl, C¿1-4?alkoxy, arylC¿1-4?alkoxy, C¿1-4?alkylthio, C¿1-4?alkoxyC¿1-4?alkyl, C¿3-6?cycloalkylC¿1-4?alkoxy, C¿1-4?alkanoyl, C¿1-4?alkoxycarbonyl, C¿1-4?alkylsulfonyl, C¿1-4?alkylsulfonyloxy, C¿1-4?alkylsulfonylC¿1-4?alkyl, arylsulfonyl, arylsulfonyloxy, arylsulfonylC¿1-4?alkyl, C¿1-4?alkylsulfonamido, C¿1-4?alkylamido, C¿1-4?alkylsulfonamidoC¿1-4?alkyl, C¿1-4?alkylamidoC¿1-4?alkyl, arylsulfonamido, arylcarboxamido, arylsulfonamidoC¿1-4?alkyl, arylcarboxamidoC¿1-4?alkyl, aroyl, aroylC¿1-4?alkyl, or arylC¿1-4?alkanoyl group; a group R?5¿OCO(CH¿2?)¿p?, R?5¿CON(R?6¿)(CH¿2?)¿p?, R?5¿R?6¿NCO(CH¿2?)¿p? or R?5¿R?6¿NSO¿2?(CH¿2?)¿p? where each of R?5¿ and R?6¿ independently represents a hydrogen atom or a C¿1-4?alkyl group or R?5¿R?6¿ forms part of a C¿3-6?azacycloalkane or C¿3-6?(2-oxo)azacycloalkane ring and p represents zero or an integer from 1 to 4; or a group Ar?3¿-Z, wherein Ar?3¿ represents an optionally substituted phenyl ring or an optionally substituted 5- or 6- membered aromatic heterocyclic ring and Z represents a bond, O, S, or CH¿2?; R?2¿ represents a hydrogen atom or a C¿1-4?alkyl group; R?3¿ and R?4¿ each independently represent a C¿1-4? alkyl group, q is 1 or 2; A represents a group of the formula (a), (b), (c) or (d).
(FR)L'invention concerne des composés de formule (I). Dans ladite formule, R?1¿ représente un substituant pouvant être : atome d'hydrogène ou d'halogène; groupe hydroxy, cyano, nitro, trifluorométhyle, trifluorométhoxy, trifluorométhanesulfonyloxy, pentafluoroéthyle, alkyle C¿1-4?, alcoxy C¿1-4?, arylalcoxy C¿1-4?, alkyle C¿1-4?thio, alcoxy C¿1-4?alkyle C¿1-4?, cycloaylkyle C¿3-6? alcoxy C¿1-4?, alkanoyle C¿1-4?, alcoxy C¿1-4?carbonyle, alkyle C¿1-4?sulfonyle, alkyle C¿1-4?sulfonyloxy, alkyle C¿1-4?sulfonylalkyle C¿1-4?, arylsulfonyle, arylsulfonyloxy, arylsulfonylalkyle C¿1-4?, alkyle C¿1-4?sulfonamido, alkyle C¿1-4?amido alkyle C¿1-4?sulfonamidoalkyle C¿1-4?,alkyle C¿1-4?amidoalkyle C¿1-4?, arylsulfonamido, arylcarboxamido, arylsulfonamidoalkyle C¿1-4?, arylcarboxamidoalkyle C¿1-4?, aroyle, aroylalkyle C¿1-4? ou arylalkanoyle C¿1-4?; un groupe R?5¿OCO(CH¿2?)¿p?, R?5¿CON(R?6¿)(CH¿2?)¿p?, R?5¿R?6¿NCO(CH¿2?)¿p?, ou R?5¿R?6¿NSO¿2?(CH¿2?)¿p?, R?5¿ et? ¿R?6¿ étant chacun indépendamment un atome d'hydrogène ou un groupe alkyle C¿1-4?, ou bien R?5¿R?6¿ faisant partie intégrante d'une chaîne C¿3-6? azacyloalkane ou C¿3-6? (2-oxo)azacyloalkane, p valant 0 ou ayant une valeur d'entier comprise entre 1 et 4; ou un groupe Ar?3¿-Z, Ar?3¿ étant une chaîne phényle éventuellement substituée ou une chaîne aromatique hétérocyclique éventuellement substituée à 5 ou 6 éléments, et Z étant une liaison O, S ou CH¿2?; R?2¿ est un atome d'hydrogène ou un groupe alkyle C¿1-4?; R?3¿ et R?4¿ sont chacun indépendamment un groupe alkyle C¿1-4?; q vaut 1 ou 2; A est un groupe de formule (a), (b), (c) ou (d).
Designated States: CA, JP, US.
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)