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1. WO2000020579 - SPLICED FORM OF $i(ERB)B-2/NEU ONCOGENE

Publication Number WO/2000/020579
Publication Date 13.04.2000
International Application No. PCT/CA1999/000912
International Filing Date 01.10.1999
Chapter 2 Demand Filed 01.05.2000
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
71
for growth factors; for growth regulators
A61K 38/00 (2006.01)
A61K 48/00 (2006.01)
C07K 14/71 (2006.01)
CPC
A61K 38/00
A61K 48/00
C07K 14/71
Applicants
  • McMASTER UNIVERSITY [CA/CA]; Health Science Centre Room 3N43 1200 Main Street Hamilton, Ontario L8N 3Z5, CA (AllExceptUS)
  • MULLER, William, J. [CA/CA]; CA (UsOnly)
  • SIEGEL, Peter, M. [CA/CA]; CA (UsOnly)
Inventors
  • MULLER, William, J.; CA
  • SIEGEL, Peter, M.; CA
Agents
  • BERESKIN & PARR; 40th floor 40 King Street West Toronto, Ontario M5H 3Y2, CA
Priority Data
09/165,19202.10.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SPLICED FORM OF $i(ERB)B-2/NEU ONCOGENE
(FR) FORME EPISSEE DE L'ONCOGENE $i(ERB)B-2/NEU
Abstract
(EN)
A novel spliced form of $i(erb)B-2 oncogene that encodes a constitutively tyrosine phosphorylated $i(erb)B-2 receptor is described. The protein has an in frame deletion of 16 amino acids, two of which are conserved cysteine residues. The protein may be useful in developing remedies to control cell transformation such as in breast cancer.
(FR)
Cette invention se rapporte à une nouvelle forme épissée de l'oncogène $i(Erb)-2 qui code un récepteur d'$i(Erb)-2 à phosphorylation constitutive par la tyrosine. Cette protéine présente une délétion dans le cadre de16 acides aminés, dont deux sont des restes systéine conservés. Cette protéine peut servir à mettre au point des remèdes pour limiter la transformation cellulaire, telle qu'elle se produit notamment dans le cancer du sein.
Also published as
Latest bibliographic data on file with the International Bureau