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1. WO2000017624 - MINIATURIZED CELL ARRAY METHODS AND APPARATUS FOR CELL-BASED SCREENING

Publication Number WO/2000/017624
Publication Date 30.03.2000
International Application No. PCT/US1999/021729
International Filing Date 22.09.1999
Chapter 2 Demand Filed 19.04.2000
IPC
B01J 19/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
G01N 15/14 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
10Investigating individual particles
14Electro-optical investigation
CPC
B01J 19/0046
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
B01J 2219/00315
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00279Features relating to reactor vessels
00306Reactor vessels in a multiple arrangement
00313the reactor vessels being formed by arrays of wells in blocks
00315Microtiter plates
B01J 2219/00317
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00279Features relating to reactor vessels
00306Reactor vessels in a multiple arrangement
00313the reactor vessels being formed by arrays of wells in blocks
00315Microtiter plates
00317Microwell devices, i.e. having large numbers of wells
B01J 2219/00351
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00351Means for dispensing and evacuation of reagents
B01J 2219/00353
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00351Means for dispensing and evacuation of reagents
00353Pumps
B01J 2219/00389
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00351Means for dispensing and evacuation of reagents
00389Feeding through valves
Applicants
  • CELLOMICS, INC. [US]/[US] (AllExceptUS)
  • JUNG, David, R. [US]/[US] (UsOnly)
  • GOUGH, Albert, H. [US]/[US] (UsOnly)
  • TAYLOR, D., Lansing [US]/[US] (UsOnly)
Inventors
  • JUNG, David, R.
  • GOUGH, Albert, H.
  • TAYLOR, D., Lansing
Agents
  • HARPER, David, S.
Priority Data
60/101,39922.09.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MINIATURIZED CELL ARRAY METHODS AND APPARATUS FOR CELL-BASED SCREENING
(FR) METHODES ET APPAREIL DE CRIBLAGE SUR LA BASE DE CELLULES AVEC UN RESEAU MINIATURISE DE CELLULES
Abstract
(EN)
The present invention devices and methods for maximizing the number of wells that can be imaged at one time while still obtaining adequate pixel resolution in the image. This result has been achieved through the use of fluidic architectures that maximizes well density. The present invention thus provides a miniaturized microplate system with closed fluidic volumes that are internally supplied with fluid exchange, and with wells that are closely spaced to more rapidly detect spatially-resolved features of individual cells.
(FR)
La présente invention concerne des dispositifs et méthodes permettant d'accroître le nombre de cupules pouvant être représentées en une seule fois tout en réalisant une définition de pixels appropriée dans l'image. On a obtenu ce résultat grâce à l'utilisation d'architectures fluidiques qui accroissent la densité des cupules. La présente invention concerne donc un système de microplaques miniaturisées comportant des volumes fluidiques fermés alimentés de façon interne par échange de fluides, et des cupules rapprochées pour une détection rapide de caractéristiques à définition spatiale de cellules individuelles.
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