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1. WO2000016796 - CHEMOKINE RECEPTOR ANTAGONIST AND CYCLOSPORIN IN COMBINED THERAPY

Publication Number WO/2000/016796
Publication Date 30.03.2000
International Application No. PCT/EP1999/006844
International Filing Date 16.09.1999
Chapter 2 Demand Filed 27.03.2000
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/13 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides
13Cyclosporins
A61K 38/19 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
A61K 45/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A61P 37/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
06Immunosuppressants, e.g. drugs for graft rejection
CPC
A61P 37/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
06Immunosuppressants, e.g. drugs for graft rejection
C07K 14/521
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
521Chemokines
Y10S 514/885
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
514Drug, bio-affecting and body treating compositions
885Immune response affecting drug
Applicants
  • APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. [NL]/[NL] (AllExceptUS)
  • GRONE, Hermann-Joseph [DE]/[DE] (UsOnly)
  • NELSON, Peter, J. [US]/[US] (UsOnly)
  • PROUDFOOT, Amanda [GB]/[FR] (UsOnly)
  • WELLS, Timothy, N., C. [GB]/[FR] (UsOnly)
Inventors
  • GRONE, Hermann-Joseph
  • NELSON, Peter, J.
  • PROUDFOOT, Amanda
  • WELLS, Timothy, N., C.
Agents
  • PIERACCIOLI, Daniele
Priority Data
98117697.718.09.1998EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CHEMOKINE RECEPTOR ANTAGONIST AND CYCLOSPORIN IN COMBINED THERAPY
(FR) ANTAGONISTE DU RECEPTEUR DE LA CHIMIOKINE ET CYCLOSPORINE EN THERAPIE COMBINEE
Abstract
(EN)
The use of a chemokine receptor antagonist together with a cyclosporin to produce a pharmaceutical composition for treating or preventing rejection of transplanted organs, tissues or cells is herein disclosed. Said pharmaceutical compositions for the simultaneous, separate or sequential use of its active ingredients for the above specified therapy are also disclosed and claimed. In particular, the use of Met-RANTES together with cyclosporin A to produce a pharmaceutical composition for the treatment of renal allograft transplant rejection is experimentally shown.
(FR)
L'invention concerne un antagoniste du récepteur de la chimiokine utilisé avec une cyclosporine pour produire une composition pharmaceutique destinée à traiter ou à prévenir le rejet d'organes, de tissus ou de cellules greffés. L'invention traite également desdites compositions pharmaceutiques conçues pour une utilisation de façon simultanée, séparée ou séquentielle de leurs principes actifs pour la thérapie susmentionnée. En particulier, l'utilisation de Met-Rantes avec de la cyclosporine A pour produire une composition pharmaceutique destinée au traitement du rejet d'une allogreffe rénale est illustrée expérimentalement.
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