WO2000015194 CALCIUM PHOSPHATE DELIVERY VEHICLE AND ADJUVANT

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Publication Number WO/2000/015194

Publication Date 23.03.2000

International Application No. PCT/US1999/021182

International Filing Date 14.09.1999

Chapter 2 Demand Filed 13.04.2000

IPC

CPC

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Applicants

ETEX CORPORATION [US]/[US]

Inventors

LEE, Dosuk, D.
AIOLOVA, Maria

Agents

SCOZZAFAVA, Mary, Rose

Priority Data

09/153,133

15.09.1998

Publication Language English (en)

Filing Language English (EN)

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Title

(EN) CALCIUM PHOSPHATE DELIVERY VEHICLE AND ADJUVANT

(FR) VECTEUR ET ADJUVANT POUR ADMINISTRATION DU PHOSPHATE DE CALCIUM

Abstract

(EN) An improved calcium phosphate delivery vehicle or adjuvant with incorporated adjuvanticity enhancing means and methods of producing same are disclosed. The adjuvant can be fabricated to desired formulations as appropriate and based on the intended purpose. Particle sizes can be adjusted to enhance adjuvant activity. Other supplemental materials may be added as desired and in appropriate proportions to selectively elicit preferred components of the immune system and to enhance the adjuvant's effect on the host response.

(FR) La présente invention concerne un vecteur et un adjuvant améliorés pour l'administration du phosphate de calcium avec des moyens intégrés propre à accroître l'effet de l'adjuvant, et des procédés de fabrication de ces substances. L'adjuvant peut être fabriqué, au gré des besoins et selon l'objectif recherché, sous forme de préparations diverses. Il est possible de jouer sur la taille des particules pour accroître l'activité de l'adjuvant. On peut ajouter d'autres matières pour solliciter des composants recherchés du système immunitaire et accroître l'effet de l'adjuvant sur la réponse hôte.

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
14	Particulate form, e.g. powders

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39	Medicinal preparations containing antigens or antibodies
39	characterised by the immunostimulating additives, e.g. chemical adjuvants

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
02	Inorganic compounds

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form

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1. WO2000015194 - CALCIUM PHOSPHATE DELIVERY VEHICLE AND ADJUVANT

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
F	FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2	Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
02	Prostheses implantable into the body
28	Bones

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
L	METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2300	Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
40	characterised by a specific therapeutic activity or mode of action
426	Immunomodulating agents, i.e. cytokines, interleukins, interferons

C	CHEMISTRY; METALLURGY
01	INORGANIC CHEMISTRY
B	NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; ; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
25	Phosphorus; Compounds thereof
16	Oxyacids of phosphorus; Salts thereof

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
14	Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
141	Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
143	with inorganic compounds