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1. WO2000015188 - COSMETIC OR DERMOPHARMACEUTICAL USE OF PEPTIDES FOR HEALING, HYDRATING AND IMPROVING SKIN APPEARANCE DURING NATURAL OR INDUCED AGEING (HELIODERMIA, POLLUTION)

Publication Number WO/2000/015188
Publication Date 23.03.2000
International Application No. PCT/FR1999/002178
International Filing Date 13.09.1999
Chapter 2 Demand Filed 04.03.2000
IPC
A61K 8/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
02characterised by special physical form
04Dispersions; Emulsions
A61K 8/64 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
64Proteins; Peptides; Derivatives or degradation products thereof
A61Q 19/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
A61Q 19/08 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
08Anti-ageing preparations
CPC
A61K 2800/57
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2800Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
40Chemical, physico-chemical or functional or structural properties of particular ingredients
57Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
A61K 8/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
02characterised by special physical form
04Dispersions; Emulsions
A61K 8/64
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
64Proteins; Peptides; Derivatives or degradation products thereof
A61K 8/645
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
64Proteins; Peptides; Derivatives or degradation products thereof
645Proteins of vegetable origin; Derivatives or degradation products thereof
A61P 17/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
16Emollients or protectives, e.g. against radiation
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applicants
  • SEDERMA S.A. [FR]/[FR] (AllExceptUS)
  • LINTNER, Karl [FR]/[FR] (UsOnly)
Inventors
  • LINTNER, Karl
Priority Data
98/1153315.09.1998FR
Publication Language French (fr)
Filing Language French (FR)
Designated States
Title
(EN) COSMETIC OR DERMOPHARMACEUTICAL USE OF PEPTIDES FOR HEALING, HYDRATING AND IMPROVING SKIN APPEARANCE DURING NATURAL OR INDUCED AGEING (HELIODERMIA, POLLUTION)
(FR) UTILISATION COSMETIQUE OU DERMAPHARMACEUTIQUE DE PEPTIDES POUR LA CICATRISATION, L'HYDRATATION ET L'AMELIORATION DE L'ASPECT CUTANE LORS DU VIEILLISSEMENT NATUREL OU ACCELERE (HELIODERMIE, POLLUTION)
Abstract
(EN) The invention concerns the use of peptides of general sequence X-Thr-Thr-Lys-Y, wherein in particular X = lysine and Y = serine, in cosmetic or dermopharmaceutical compositions. It is moreover advantageous to use said peptides in mutual combination. In order to enhance their activity and their stability, the peptides are chemically modified to increase their lipophilicity, by grafting on the N-terminal amine of X, either a fatty acid chain, or by esterification or amidation of the C-terminal carboxyl group of Y. The peptides can be obtained by synthesis, biotechnology or controlled hydrolysis or plant proteins. The resulting compositions are advantageously used for stimulating healing, hydrating or all skin treatments. They are particularly active against formation or deterioration of wrinkles and against all the consequences of skin ageing, whether natural or induced (heliodermia, pollution), as well as for dry skin.
(FR) Le brevet décrit l'utilisation de peptides de séquence générale X-Thr-Thr-Lys-Y, avec notamment X = lysine et Y = sérine, dans des compositions cosmétiques ou dermopharmaceutiques. De plus il peut être avantageux d'utiliser ces peptides en combinaison entre eux. Afin de renforcer leur activité et leur stabilité, les peptides sont modifiés chimiquement pour augmenter leur lipophilie, par le greffage sur l'amine N-terminale de X, soit d'une chaîne d'acide gras, soit par l'estérification ou l'amidation du groupe carboxyle C-terminal de Y. Les peptides peuvent être obtenus par synthèse, par biotechnologie ou par hydrolyse ménagée de protéines végétales. Les compositions obtenues sont avantageusement utilisées pour favoriser la cicatrisation, l'hydratation, et pour tous les soins de la peau. Elles agissent particulièrement contre la formation et l'aggravation des rides et contre toutes les conséquences du vieillissement cutané, naturel ou accéléré (héliodermie, pollution), ainsi que dans le dessèchement cutané.
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