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1. WO2000014240 - ATTENUATED SALMONELLA SP12 MUTANTS AS ANTIGEN CARRIERS

Publication Number WO/2000/014240
Publication Date 16.03.2000
International Application No. PCT/EP1999/006514
International Filing Date 03.09.1999
Chapter 2 Demand Filed 22.03.2000
IPC
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/255 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
24from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
255Salmonella (G)
CPC
A61K 2035/11
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
11Medicinal preparations comprising living procariotic cells
A61K 2039/522
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
52Bacterial cells; Fungal cells; Protozoal cells
522avirulent or attenuated
A61K 2039/523
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
52Bacterial cells; Fungal cells; Protozoal cells
523expressing foreign proteins
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
Applicants
  • CREATOGEN AKTIENGESELLSCHAFT [DE]/[DE] (AllExceptUS)
  • HENSEL, Michael [DE]/[DE] (UsOnly)
  • GUZMÁN, Carlos, Alberto [AR]/[DE] (UsOnly)
  • MEDINA, Eva [ES]/[DE] (UsOnly)
  • APFEL, Heiko [DE]/[DE] (UsOnly)
  • HUECK, Christoph [DE]/[DE] (UsOnly)
Inventors
  • HENSEL, Michael
  • GUZMÁN, Carlos, Alberto
  • MEDINA, Eva
  • APFEL, Heiko
  • HUECK, Christoph
Agents
  • WEICKMANN, H.
Priority Data
98116827.104.09.1998EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ATTENUATED SALMONELLA SP12 MUTANTS AS ANTIGEN CARRIERS
(FR) MUTANTS ATTENUES DE SPI2 DE SALMONELLES UTILISES COMME PORTEURS D'ANTIGENES
Abstract
(EN)
The present invention relates to vaccines, in particular, to an attenuated gram-negative cell comprising the SPI2 gene locus, wherein at least one gene of the SPI2 locus is inactivated, wherein said inactivation results in an attenuation/reduction of virulence compared to the wild type of said cell, and to a carrier for the presentation of an antigen to a host, which carrier is said attenuated gram-negative cell, wherein said cell comprises at least one heterologous nucleic acid molecule comprising a nucleic acid sequence coding for said antigen, wherein said cell is capable of expressing said nucleic acid molecule or capable of causing the expression of said nucleic acid molecule in a target cell.
(FR)
L'invention porte sur des vaccins et en particulier sur des cellules gram-négatives comprenant le locus de gènes du SPI2, l'un au moins des gènes du locus du SPI2 étant inactivé, ladite inactivation se traduisant par une atténuation/réduction de la virulence par comparaison au type sauvage de ladite cellule. L'invention porte également sur un porteur de présentation d'un antigène à un hôte constitué par ladite cellule gram-négative atténuée. Cette dernière comporte au moins une séquence d'acide nucléique codant pour ledit antigène et capable d'exprimer ladite molécule d'acide nucléique et d'en causer l'expression dans une cellule cible.
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