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1. WO2000014155 - ERODIBLE SOLID HYDROGELS FOR DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS

Publication Number WO/2000/014155
Publication Date 16.03.2000
International Application No. PCT/GB1999/002960
International Filing Date 07.09.1999
Chapter 2 Demand Filed 07.04.2000
IPC
A61K 9/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
C08B 37/08 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
BPOLYSACCHARIDES; DERIVATIVES THEREOF
37Preparation of polysaccharides not provided for in groups C08B1/-C08B35/110; Derivatives thereof
08Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
C08J 3/075 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H142
3Processes of treating or compounding macromolecular substances
02Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
03in aqueous media
075Macromolecular gels
CPC
A61K 9/205
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2022Organic macromolecular compounds
205Polysaccharides, e.g. alginate, gums; Cyclodextrin
A61K 9/2095
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
C08B 37/003
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
BPOLYSACCHARIDES; DERIVATIVES THEREOF
37Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
0024beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
00272-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
003Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
C08J 2305/08
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G
2305Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
08Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
C08J 3/075
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G
3Processes of treating or compounding macromolecular substances
02Making solutions, dispersions or lattices by other methods than by solution, emulsion or suspension polymerisation techniques
03in aqueous media
075Macromolecular gels
Applicants
  • UNIVERSITY OF STRATHCLYDE [GB]/[GB] (AllExceptUS)
  • UCHEGBU, Ijeoma, Florence [GB]/[GB] (UsOnly)
Inventors
  • UCHEGBU, Ijeoma, Florence
Agents
  • McCALLUM, William, Potter
Priority Data
9819461.608.09.1998GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ERODIBLE SOLID HYDROGELS FOR DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS
(FR) HYDROGELS SOLIDES UTILISABLES POUR L'ADMINISTRATION D'AGENTS A ACTIVITE BIOLOGIQUE
Abstract
(EN)
The present invention is directed to an erodible solid hydrogel material for delivery of biologically active agents such as pharmaceuticals. Said solid hydrogel material is formed from non-covalently cross-linked polysaccharide derivatives, which bear both hydrophilic and hydrophobic groups. Gel formation is then induced for example by freeze-drying. The gel is erodible either by simple mechanical disruption of the gel or due to biological processes acting on the hydrogel.
(FR)
L'invention porte sur un hydrogel solide utilisable pour l'administration d'agents à activité biologique, tels que des produits pharmaceutiques. Ledit hydrogel se compose de dérivés de polysaccharides non réticulés par covalence porteurs de groupes hydrophiles et hydrophobes. La formation du gel s'obtient par exemple par lyophilisation. Ledit gel est érodable soit par simple fragmentation mécanique, soit sous l'effet d'un processus biologique agissant sur l'hydrogel.
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